{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:06:45Z","timestamp":1763366805252},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4373,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the maternal serum cancer antigen 125 (MS\u2010CA 125) levels in 98 nonpregnant women, 765 first\u2010 and second\u2010trimester pregnancies with chromosomally\u2010normal fetuses, and 54 chromosomally\u2010abnormal pregnancies. To determine the MS\u2010CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter\u2010assay variability. The median MS\u2010CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non\u2010pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t\u2010test: t = 0\u00b757, <jats:italic>p<\/jats:italic> &gt;0\u00b75). The MS\u2010CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS\u2010CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy.<\/jats:p>","DOI":"10.1002\/pd.1970131207","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:39:44Z","timestamp":1172990384000},"page":"1123-1131","source":"Crossref","is-referenced-by-count":13,"title":["Maternal serum CA 125 levels in pregnancies with chromosomally\u2010normal and \u2010abnormal fetuses"],"prefix":"10.1002","volume":"13","author":[{"given":"J. M. M.","family":"Van Lith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mantingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W. A.","family":"De Bruijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"For the Dutch Working Party on Prenatal Diagnosis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90981-C"},{"key":"e_1_2_1_3_1","first-page":"742","article-title":"Serum CA 125 levels in early pregnancy and subsequent spontaneous abortion","volume":"75","author":"Check J. H.","year":"1990","journal-title":"Obstet. 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