{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T20:23:01Z","timestamp":1700166181353},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4342,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Of 2882 women allocated to either transabdominal CVS (TA) or transcervical CVS (TC) at two large obstetric centres in Denmark, 2707 had blood samples drawn before and 30 min after CVS for maternal serum\u2010alpha\u2010fetoprotein (MSAFP) measurement. 2535 of these women had cytogenetically normal pregnancies and 2091 of them went on to have samples drawn at the 18\u201320 week follow\u2010up. Post\u2010procedure MSAFP values were correlated to the biopsy method used, with mean MSAFP values significantly higher after TA than TC, 33 and 15 kU\/l, respectively (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). Following TA procedures, 18 per cent of cases had feto\u2010maternal transfusion higher than 0\u00b71 ml; this occurred in only 5 per cent of TC cases. MSAFP levels were associated with spontaneous fetal loss in the TA group but not in the TC group. TC, however, was followed by more losses than TA. The post\u2010CVS MSAFP value was positively correlated with the amount of villi aspirated. The difference in post\u2010procedure elevation in MSAFP 30 min later (average 18 kU\/l higher for TA than for TC) was not reflected in raised levels at the 18\u201320 week follow\u2010up. Study medians at mid\u2010trimester did not differ from reference group medians established from a group of singleton pregnancies with sonographically determined gestational age who did not experience invasive procedures and delivered normal infants. Our findings suggest that CVS does not compromise mid\u2010trimester MSAFP for screening for neural tube defects (NTDs). Extremely high mid\u2010trimester MSAFP values in the TC group could predict imminent loss.<\/jats:p>","DOI":"10.1002\/pd.1970140107","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:51:42Z","timestamp":1172991102000},"page":"35-45","source":"Crossref","is-referenced-by-count":22,"title":["Implications of maternal serum alpha\u2010fetoprotein elevation caused by transabdominal and transcervical CVS"],"prefix":"10.1002","volume":"14","author":[{"given":"Steen","family":"Smidt\u2010Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M.","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bent","family":"N\u00f8rgaard\u2010Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070805"},{"key":"e_1_2_1_3_1","first-page":"20","article-title":"Fetale erytrocyten im m\u00fctterlichen blut und immunoprophylaxe der Rh immunisierung","volume":"51","author":"Bartsch F. K.","year":"1972","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136340"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020105"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105486"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1979.tb10802.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92373-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091590403"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(88)90039-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6073.1377"},{"key":"e_1_2_1_12_1","first-page":"60","article-title":"Fetomaternal bleeding following diagnostic amniocentesis","volume":"60","author":"Lele A. S.","year":"1982","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","unstructured":"Lilford R. J. Linton G. Irving H. C. Mason M. K.(1987). Transabdominal chorion villus biopsy: 100 consecutive cases Lancet June 20 1415\u20131416.","DOI":"10.1016\/S0140-6736(87)90602-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196810102791508"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92333-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060110"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1990.tb03388.x"},{"key":"e_1_2_1_18_1","first-page":"498","article-title":"Malformation and deformation of the animal embryo","volume":"4","author":"Poswillo D. E.","year":"1971","journal-title":"Teratology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90259-J"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90667-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100708"},{"key":"e_1_2_1_22_1","first-page":"189","volume-title":"Intrauterine Development","author":"Schruefer J.","year":"1968"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90013-W"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb25402.x"},{"key":"e_1_2_1_25_1","first-page":"875","article-title":"Maternal serum alpha\u2010fetoprotein screening after chorionic villus sampling","volume":"70","author":"Sigler M. E.","year":"1987","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040308"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040302"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060208"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92946-D"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/46.1.36"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6546.533"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3219.439"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.130.3381.981"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6377.1542"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91345-5"},{"key":"e_1_2_1_36_1","first-page":"1245","article-title":"The pathogenesis and prevention of Rh immunization","volume":"97","author":"Zipursky A.","year":"1967","journal-title":"Can. Med. Assoc. J."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970140107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970140107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:10:42Z","timestamp":1698156642000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970140107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/pd.1970140107"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970140107","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}