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The average time needed for notification of the analysed karyotype was 4\u00b765 days when the \u2018pipette method\u2019 was used for chromosome harvesting and 5\u00b797 days when the \u2018<jats:italic>in situ<\/jats:italic>\u2019 technique was used. The overall incidence of chromosome aberrations was 15\u00b73 per cent. Data are presented about the likelihood of abnormal ultrasound findings being caused by chromosome aberrations. These findings include polyhydramnios, oligohydramnios, growth retardation, fetal effusions, neural tube defects, craniofacial defects, heart defects, gastroschisis and omphalocele, gastrointestinal tract defects, urinogenital defects, and limb defects. In future, such data need to contain larger numbers of cases for each week of gestation. This will improve the risk evaluation for each case with abnormal ultrasound findings, which should lead to better management during pregnancy, delivery, and postnatal care for those who require rapid karyotyping.<\/jats:p>","DOI":"10.1002\/pd.1970140207","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:35:40Z","timestamp":1173000940000},"page":"113-121","source":"Crossref","is-referenced-by-count":13,"title":["Six years' experience with rapid karyotyping in prenatal diagnosis: Correlations between phenotype detected by ultrasound and fetal karyotype"],"prefix":"10.1002","volume":"14","author":[{"given":"Uwe","family":"Claussen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Ulmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Beinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Joachim","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080413"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091403"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278985"},{"key":"e_1_2_1_5_1","first-page":"33","article-title":"Die \u2018Pipetten\u2010methode\u2019 zur schnellen Karyotypisierung bei sonographischem Verdacht f\u00fcr eine Chromosomenanomalie","volume":"17","author":"Claussen U.","year":"1984","journal-title":"Gyn\u00e4kologe"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060603"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970131203"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970121003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6222.1107"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970030402"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80254-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110821"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090405"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb03070.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090902"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90152-4"},{"key":"e_1_2_1_17_1","first-page":"261","article-title":"Transabdominale und transcervikale Chorionbiopsien","volume":"23","author":"Holzgreve W.","year":"1990","journal-title":"Gyn\u00e4kologe"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90014-X"},{"key":"e_1_2_1_19_1","first-page":"855","article-title":"The natural history of cytogenetically abnormal fetuses detected at midtrimester amniocentesis which are not terminated electively: new data and estimates of the excess and relative risk of late fetal death associated with 47, +21 and some other abnormal karyotypes","volume":"45","author":"Hook E. 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