{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:11:43Z","timestamp":1757704303432},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic counselling in a dizygotic twin pregnancy is complicated by the large number of possible pregnancy outcomes and by the conceivable differences in the parental valuation of these outcomes. We present the probability distributions of the pregnancy outcomes in dizygotic twin pregnancies for women from 35 to 45 years old without prenatal diagnosis and with transabdominal chorionic villus sampling (TA\u2010CVS) or amniocentesis (AC), using data from the literature. TA\u2010CVS always gives a higher probability of a favourable pregnancy outcome (the birth of one or two infants with a normal karyotype) than AC. For a 35\u2010year\u2010old woman, a 0\u00b77 per cent risk of an unfavourable pregnancy outcome without prenatal diagnosis has to be weighed against the 2\u00b71 per cent excess risk of loss of the entire pregnancy after TA\u2010CVS. For a 45\u2010year\u2010old woman, a 10\u00b72 per cent risk of an unfavourable pregnancy outcome without TA\u2010CVS has to be balanced against a 4\u00b74 per cent excess risk of pregnancy loss after TA\u2010CVS. This study provides a quantitative tool for the support of individual parents with respect to the decision to undergo prenatal diagnosis in a dizygotic twin pregnancy.<\/jats:p>","DOI":"10.1002\/pd.1970140404","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:46:58Z","timestamp":1173001618000},"page":"243-256","source":"Crossref","is-referenced-by-count":12,"title":["A quantitative estimation of the effect of prenatal diagnosis in dizygotic twin pregnancies in women of advanced maternal age"],"prefix":"10.1002","volume":"14","author":[{"given":"H.","family":"Brandenburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H. P. Der","family":"Van Meulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G. J.","family":"Jahoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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