{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:01:58Z","timestamp":1768874518984,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic analysis was performed in 4860 chorionic villus samples by means of both direct preparation and long\u2010term culture. The results of the analysis were compared with a classification including all theoretical types of combinations between the chromosomal constitution of the cytotrophoblast, extraembryonal mesoderm, and fetus, with the aim of evaluating the cytogenetic variability along the trophoblast\u2014embryo axis. Eighteen of 29 possible combinations were found demonstrating a considerable heterogeneity. A mosaic conceptus was found in 1\u00b75 per cent of cases, with generalized mosaicisms and confined mosaicisms in 0\u00b72 and 1\u00b73 per cent, respectively. Cytogenetic variability along the trophoblast\u2014embryo axis was found in 1\u00b742 per cent of cases. Results possibly leading to diagnostic errors (false\u2010positive and false\u2010negative results) were found in only 1\u00b738 per cent. False\u2010positive results of direct preparation were the most commonly observed discrepancy (0\u00b78 per cent), while the incidence of false\u2010positive results of the culture method and of both methods was 0\u00b731 and 0\u00b716 per cent respectively. The incidence of false\u2010negative results was 0\u00b71 per cent, with false\u2010negative results of direct preparation 0\u00b708 per cent and false\u2010negative results of both methods 0\u00b702 per cent. False\u2010negative results of the culture method were not found. Our data confirm the high diagnostic accuracy of chorionic villus sampling and the utility of the combined use of the two methods in minimizing diagnostic errors and in reducing the need for follow\u2010up amniocentesis.<\/jats:p>","DOI":"10.1002\/pd.1970140406","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:46:58Z","timestamp":1173001618000},"page":"267-278","source":"Crossref","is-referenced-by-count":58,"title":["The predictive value of cytogenetic diagnosis after CVS based on 4860 cases with both direct and culture methods"],"prefix":"10.1002","volume":"14","author":[{"given":"M. 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