{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:48:06Z","timestamp":1751438886948},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three cases of hydrops fetalis presented in the second trimester as screen\u2010positive for Down syndrome using multiple maternal serum markers. One case was a karyotypically normal female; one case was a monosomy X (Turner syndrome); and one case was a trisomy 21 (Down syndrome). In each case, the maternal serum human chorionic gonadotrophin (hCG) was disproportionately elevated. These cases support the contention that hydrops fetalis of any aetiology may present as screen\u2010positive when using multiple maternal serum markers for Down syndrome. Further cases will be necessary before it can be determined whether a disproportionately elevated hCG is predictive of hydrops.<\/jats:p>","DOI":"10.1002\/pd.1970140510","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:43:16Z","timestamp":1173001396000},"page":"403-405","source":"Crossref","is-referenced-by-count":18,"title":["Multiple marker screen positivity in the presence of hydrops fetalis"],"prefix":"10.1002","volume":"14","author":[{"given":"Simon","family":"Knowles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Flett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Bower C. Rudy E. Ryan A. Forbes R. Stanley F. J.(1992).Report of the Birth Defects Registry of Western Australia1980\u20131991."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(84)90074-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198709000-00003"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100813"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198909000-00008"},{"key":"e_1_2_1_7_1","first-page":"131","article-title":"Circulating placental proteins in pregnancies complicated by Rh isoimmunisation","volume":"64","author":"Lee J.\u2010N.","year":"1984","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90700-H"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91139-N"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)80031-7"},{"key":"e_1_2_1_11_1","first-page":"1025","article-title":"A maternal serum screen for trisomy 18: an extension of maternal serum screening for Down syndrome","volume":"49","author":"Staples A. J.","year":"1991","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6653.883"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb14474.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970140510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970140510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:31:08Z","timestamp":1698107468000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970140510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["10.1002\/pd.1970140510"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970140510","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}