{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:56:55Z","timestamp":1761101815266},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4192,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We wished to identify the types and frequencies of malformations among continuing pregnancies exposed to chorionic villus sampling (CVS) and to determine whether selected procedure\u2010related variables differ between the normal and anomalous cohorts. CVS was performed in 1048 patients between May 1988 and January 1992. Prospective assessment of perinatal outcome was ascertained by (1) physician\u2014patient phone contact within 1 week of sampling, (2) ultrasound evaluation of the fetal anatomy at mid\u2010gestation, (3) a detailed post\u2010partum questionnaire completed by the referring obstetrician, and (4) a telephone interview with each patient after the expected date of confinement. Twenty\u2010seven major malformations were documented among 938 pregnancies (live born, <jats:italic>n<\/jats:italic>=934; electively terminated, <jats:italic>n<\/jats:italic>=4), and included cardiac malformations (5), hypospadias (5), craniosynostosis (2), pyloric stenosis (2), inguinal hernia (2), polydactyly (2), syndactyly, distal extremely hemimelia, anencephaly, hydrocephalus, cleft lip and palate, omphalocele, diaphragmatic hernia, thanatophoric dysplasia, and unilateral cataract. Normal and anomalous cohorts were similar with respect to sampling method (transabdominal\/transcervical ratio), mean gestational age at CVS, single\u2010pass success rate, and mean total sample weight. No relationship between any procedure\u2010related variable and the risk of malformation was observed.<\/jats:p>","DOI":"10.1002\/pd.1970140602","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:42:48Z","timestamp":1173001368000},"page":"421-427","source":"Crossref","is-referenced-by-count":8,"title":["Congenital malformations subsequent to chorionic villus sampling: Outcome analysis of 1048 consecutive procedures"],"prefix":"10.1002","volume":"14","author":[{"given":"Richard K.","family":"Silver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott N.","family":"Macgregor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia H.","family":"Muhlbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri A.","family":"Knutel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle P.","family":"Kambich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"726","article-title":"Limb anomalies associated with chorionic villus sampling","volume":"79","author":"Burton B. K.","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Multicentre clinical trial of chorionic villus sampling and amniocentesis","volume":"1","author":"Canadian Collaborators CVS\u2010Amniocentesis Clinical Trial Group","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090110"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91374-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390205"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93293-V"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80343-0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91735-D"},{"key":"e_1_2_1_10_1","first-page":"1423","article-title":"Limb abnormalities and chorionic villus sampling (Letter)","volume":"337","author":"Jackson L. 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