{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:00Z","timestamp":1761675480739},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4192,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between gestational infection with human parvovirus (B19) and fetal loss has increased interest in this virus and demand for diagnostic testing. However, serological assays for B19 are not yet widely available. Maternal serum alpha\u2010fetoprotein (MSAFP) testing is commonly used during the second trimester to screen for various fetal defects. We attempted to determine whether an elevated level of MSAFP would be an appropriate indication for B19\u2010specific tests. Over a 26\u2010month period, MSAFP tests were performed at Michigan State University for 21 392 women. Sera remaining after that testing were stored frozen. Of these, 22 case samples\u2014from women with MSAFP levels greater than 3\u00b70 multiples of the median (MOM) and pregnancies that ended in fetal loss\u2014and 44 matched control samples\u2014from women with MSAFP levels greater than 0\u00b74 and less than 2\u00b72 MOM and live births at term\u2014were tested for B19 antibodies. None of the 66 samples was IgM positive, while 33 (50 per cent) were IgG positive. The presence of IgG was not significantly associated with case or control status (matched odds ratio=0\u00b777, 95 per cent confidence interval 0\u00b728\u20132\u00b711). These findings are consistent with other studies indicating prior infection in approximately half of adults and suggest that elevated screening MSAFP levels, in the absence of other evidence of B19 infection, should not prompt B19\u2010specific testing.<\/jats:p>","DOI":"10.1002\/pd.1970140607","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:42:48Z","timestamp":1173001368000},"page":"455-458","source":"Crossref","is-referenced-by-count":9,"title":["Screening maternal serum alpha\u2010fetoprotein levels and human parvovirus antibodies"],"prefix":"10.1002","volume":"14","author":[{"given":"David R.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny J.","family":"Helwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances P.","family":"Downes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80062-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1542\/peds.85.1.131","article-title":"Parvovirus, erythema infectiosum, and pregnancy","volume":"85","author":"American Academy of Pediatrics, Committee on Infectious Diseases","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701223160403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.24.4.522-526.1986"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91331-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91126-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90129-2"},{"key":"e_1_2_1_9_1","first-page":"81","article-title":"Risks associated with human parvovirus B19 infection","volume":"38","author":"Centers for Disease Control","year":"1989","journal-title":"M. 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