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On average, the levels of both analytes were twice as high in twins and over three times as high in triplets. Eight sets of twins discordant for Down's syndrome showed elevated levels of free beta hCG and reduced levels of AFP after correction of the multiple of the median for the presence of a twin pregnancy. Screening for Down's syndrome using the twin correction of the multiple of the median is expected to achieve a 51 per cent detection rate at a 5 per cent false\u2010positive rate using these two markers.<\/jats:p>","DOI":"10.1002\/pd.1970140705","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:42:23Z","timestamp":1173001343000},"page":"537-542","source":"Crossref","is-referenced-by-count":69,"title":["Down's syndrome screening in multiple pregnancies using alpha\u2010fetoprotein and free beta hCG"],"prefix":"10.1002","volume":"14","author":[{"given":"K.","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Salonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"294","article-title":"Mongoloid twins and their siblings","volume":"5","author":"Allen G.","year":"1955","journal-title":"Acta Genet."},{"key":"e_1_2_1_3_1","first-page":"A270","article-title":"Prenatal screening for Down syndrome using AFP, UE3 and hCG: effect of maternal race, insulindependent diabetes and twin pregnancy","volume":"47","author":"Canick J. 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