{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:47:46Z","timestamp":1698295666242},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The levels of the maternal serum markers alpha\u2010fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated oestriol (uE<jats:sub>3<\/jats:sub>) in 35 pregnant women with early second\u2010trimester oligohydramnios differed from those in a reference population of 1699 singleton pregnancies. Maternal serum AFP levels above the 95th centile of the population distribution were observed in 80 per cent (16\/20) of oligohydramnios cases with a normal fetus and in only 20 per cent (3\/15) of the cases with a fetus displaying urogenital tract malformations. Elevated levels of hCG (above the 95th centile) and decreased levels of uE<jats:sub>3<\/jats:sub> (below the fifth centile) were encountered in 26 per cent (9\/35) and 17 per cent (6\/35) of the women, irrespective of the fetal condition. The abnormal profile of the serum markers in early second\u2010trimester oligohydramnios resulted in 57 per cent (20 out of 35) of screen\u2010positive cases for either fetal Down's syndrome or neural tube defects, compared with 8\u00b74 per cent (143 out of 1699) in the reference population.<\/jats:p>","DOI":"10.1002\/pd.1970140709","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:42:23Z","timestamp":1173001343000},"page":"565-568","source":"Crossref","is-referenced-by-count":2,"title":["Maternal serum markers in second\u2010trimester oligohydramnios"],"prefix":"10.1002","volume":"14","author":[{"given":"Frans J.","family":"Los","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M.","family":"Hagenaars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titia E.","family":"Cohen\u2010Overbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik W. P.","family":"Quartero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120804"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070904"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06601.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90359-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(85)90159-5"},{"key":"e_1_2_1_7_1","first-page":"72","article-title":"A prospective evaluation of a second\u2010trimester screening test for fetal Down syndrome using maternal serum alpha\u2010fetoprotein, hCG, and unconjugated estriol","volume":"81","author":"Cheng E. Y.","year":"1993","journal-title":"Obstet. 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