{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T16:21:00Z","timestamp":1700324460920},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic data are presented from a total of 1306 consecutive pregnancies with successful diagnosis obtained from both chorionic villi after short\u2010time culture (CVS\u2010SC) and amniotic fluid cell cultures (AC); samples had been taken simultaneously at combined placentacentesis (placental biopsy) and amniocentesis during the second (92\u00b78 per cent) and third (7\u00b72 per cent) trimesters. Concordant results were obtained in 1218 pregnancies with a normal karyotype and in 62 pregnancies with an aberrant fetal karyotype. Discrepant, i. e. false\u2010positive and false\u2010negative, results were found in 26 cases (2 per cent). From these data the accuracy of CVS\u2010SC, defined as the proportion of all correct diagnoses, is calculated to be 98 per cent. Three non\u2010mosaic and 14 mosaic false\u2010positive results obtained after CVS\u2010SC could not be confirmed by AC. Related to 1235 true normal fetal karyotypes, the specificity of CVS\u2010SC, i.e. the proportion of normal karyotypes correctly diagnosed, amounts to 98\u00b76 per cent. In nine pregnancies, an aberrant fetal karyotype detected after AC was missed by CVS\u2010SC. The sensitivity of CVS\u2010SC, i.e. the proportion of abnormal fetuses correctly diagnosed (62 out of 71), amounts to 87\u00b73 per cent in our study group.<\/jats:p>","DOI":"10.1002\/pd.1970140710","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:42:23Z","timestamp":1173001343000},"page":"569-576","source":"Crossref","is-referenced-by-count":15,"title":["Discrepant karyotypes after second\u2010 and third\u2010trimester combined placentacentesis\/amniocentesis"],"prefix":"10.1002","volume":"14","author":[{"given":"D.","family":"Caspari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rauskolb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Prange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Osmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Eiben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080206"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb04264.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970121114"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100604"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100305"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100506"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272385"},{"key":"e_1_2_1_9_1","first-page":"8","article-title":"Uniparental disomy for chromosome 16 in humans","volume":"52","author":"Kalousek D. 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