{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T18:26:35Z","timestamp":1725387995189},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared the medical and financial cost\u2010effectiveness of prenatal serum screening for Down's syndrome using maternal age, serum alpha\u2010fetoprotein and human chorionic gonadotrophin with and without the use of unconjugated oestriol. The use of unconjugated oestriol is medically more cost\u2010effective than screening without it at all levels of detection. The actual performance depends on whether gestational age is estimated using \u2018dates\u2019 or an ultrasound scan. At a detection rate of 60 per cent, the proportion of unaffected fetal losses per case diagnosed at amniocentesis is about 22 per cent less if gestational age is estimated using dates (time since the first day of the last menstrual period) and about 47 per cent less if it is based on an ultrasound scan examination. At this detection rate, the inclusion of unconjugated oestriol increases costs by about \u00a32k per case diagnosed (\u00a336k instead of \u00a334k) if gestational age is estimated using dates, but it is no more expensive if gestational age is measured from an ultrasound scan examination (indeed, it is more cost\u2010effective at detection rates above 60 per cent). Since there is little change in the financial cost with the inclusion of unconjugated oestriol, for the improved medical performance of screening, it is worthwhile including it in the screening test.<\/jats:p>","DOI":"10.1002\/pd.1970140809","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:05:38Z","timestamp":1173002738000},"page":"699-706","source":"Crossref","is-referenced-by-count":6,"title":["Value of maternal serum unconjugated oestriol measurement in prenatal screening for Down's syndrome"],"prefix":"10.1002","volume":"14","author":[{"given":"Nicholas J.","family":"Wald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Kennard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary C.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06601.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130406"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/clinchem\/38.9.1687","article-title":"Measuring unconjugated estriol in maternal serum to screen for fetal Down syndrome","volume":"38","author":"Cuckle H. 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