{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:20:27Z","timestamp":1783556427676,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4070,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human chorionic gonadotrophin (hCG) is the most discriminatory maternal serum marker of Down's syndrome. We have carried out a study to establish whether urinary \u03b2\u2010core\u2010hCG, a major metabolic product of hCG, might be an even better marker. Urine samples were available from seven singleton pregnancies with Down's syndrome, and one each of Edwards' syndrome, triploidy, and twins discordant for Down's syndrome. \u03b2\u2010Core\u2010hCG levels were corrected for creatinine and expressed as multiples of the normal gestation\u2010specific median (MOM) level derived from 67 singleton controls. There was a highly statistically significant elevation in level among the singleton Down's syndrome cases (<jats:italic>P<\/jats:italic>&lt;0\u00b70005; Wilcoxon rank sum test). All had levels exceeding 2 MOM with a median of 6\u00b711 MOM (95 per cent confidence interval 3\u00b77\u201310\u00b70). The levels were extremely low in Edwards' syndrome (0\u00b708 MOM) and triploidy (0\u00b702 MOM), but the twin pregnancy discordant for Down's syndrome did not have a raised \u03b2\u2010core\u2010hCG level (0\u00b764 MOM). The findings are sufficiently encouraging to investigate the possibility of urinalysis as a routine modality in the prenatal screening for Down's syndrome and other common serious aneuploidies.<\/jats:p>","DOI":"10.1002\/pd.1970141010","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:51:35Z","timestamp":1172991095000},"page":"953-958","source":"Crossref","is-referenced-by-count":58,"title":["Urinary \u03b2\u2010core human chorionic gonadotrophin: A new approach to Down's syndrome screening"],"prefix":"10.1002","volume":"14","author":[{"given":"H. S.","family":"Cuckle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Iles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Chard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.3.704"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.2.497"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6867.1504"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6860.1017"},{"key":"e_1_2_1_6_1","first-page":"53","article-title":"Stability of immunoreactive \u03b2\u2010core fragment of hCG","volume":"1","author":"de Medeiros S. F.","year":"1991","journal-title":"Obstet. 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