{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:00Z","timestamp":1761675480545},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":4070,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated first\u2010trimester maternal serum alpha\u2010fetoprotein (MS\u2010AFP) as a marker for fetal chromosomal disorders. The multicentre study was performed under the auspices of the Dutch Working Party on Prenatal Diagnosis. MS\u2010AFP was measured in 2404 normal pregnancies and 72 chromosomally abnormal pregnancies. The median multiple of the normal median (MOM) in 32 Down's syndrome pregnancies was 0\u00b783 with a 95 per cent confidence interval ranging from 0\u00b760 to 1\u00b704. The difference between the distributions of first\u2010trimester MS\u2010AFP in normal and Down's syndrome pregnancies was statistically significant (<jats:italic>t<\/jats:italic>\u2010test: <jats:italic>t<\/jats:italic> = 2\u00b734, <jats:italic>P<\/jats:italic>&lt;0\u00b705). Thirty\u2010one per cent of the Down's syndrome pregnancies were found below the tenth percentile. We found no difference between normal pregnancies and pregnancies with other chromosomal disorders (eight cases with trisomy 18, MOM = 1\u00b726; seven cases with sex chromosome abnormalities, MOM = 1\u00b707; 22 cases with a chromosomal mosaic pattern in chorionic villi, MOM = 1\u00b708). We conclude that first\u2010trimester MS\u2010AFP can discriminate between normal and Down's syndrome pregnancies, but is not an effective marker. First\u2010trimester MS\u2010AFP has no value as a marker for other fetal chromosomal disorders.<\/jats:p>","DOI":"10.1002\/pd.1970141012","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:51:35Z","timestamp":1172991095000},"page":"963-971","source":"Crossref","is-referenced-by-count":11,"title":["First\u2010trimester maternal serum alpha\u2010fetoprotein as a marker for fetal chromosomal disorders"],"prefix":"10.1002","volume":"14","author":[{"given":"Jan M. 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