{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:04:21Z","timestamp":1792152261140,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":4052,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic studies of cultured amniocytes demonstrated a karyotype of 46, XX\/47, XX,+mar. A bisatellited, dicentric, distamycin\u2010DAPI negative, NOR\u2010positive marker was present in 76 per cent of the metaphases examined. Similar markers have been associated with cat eye syndrome (CES). We report on the utilization of fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) with a 14\/22 <jats:italic>a<\/jats:italic>\u2010satellite probe and a chromosome 22\u2010specific cosmid for locus D22S9 to determine the origin of the prenatally detected supernumerary marker chromosome. FISH studies demonstrated that the marker is a derivative of chromosome 22 and enabled us to provide the family with additional prognostic information.<\/jats:p>","DOI":"10.1002\/pd.1970141104","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T07:05:42Z","timestamp":1172991942000},"page":"1029-1034","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal diagnosis of the derivative chromosome 22 associated with cat eye syndrome by fluorescence <i>in situ<\/i> hybridization"],"prefix":"10.1002","volume":"14","author":[{"given":"Suzanne L.","family":"Reeser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Donnenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice S.","family":"Sellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1092","article-title":"Incidence and significance of supernumerary marker chromosomes in prenatal diagnosis","volume":"36","author":"Benn P. 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