{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:20:19Z","timestamp":1789579219133,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":4052,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum measurements of pregnancy\u2010associated plasma protein A (PAPP\u2010A) and the free \u03b2\u2010human chorionic gonadotrophin (hCG) subunit were made in 13 women with Down syndrome (DS) pregnancies and six other women with fetal aneuploidy ascertained at chorionic villus sampling (CVS), as well as 89 women with contemporaneous normal control pregnancies. Median serum PAPP\u2010A measurements (0\u00b731 MOM, 95 per cent confidence interval (CI) 0\u00b722\u20130\u00b765 vs. normal 1\u00b706, 95 per cent CI 0\u00b789\u20131\u00b720) were lower and free \u03b2\u2010hCG subunit measurements (1\u00b713 MOM, 95 per cent CI 0\u00b793\u20132\u00b763 vs. normal 0\u00b791, 95 per cent CI 0\u00b779\u20131\u00b703) were higher at statistically significant levels. Receiver operator characteristic (ROC) curves showed that the highest sensitivity for detection, 71\u00b72 per cent (95 per cent CI 54\u00b77\u201387\u00b76 per cent), was for depressed PAPP\u2010A levels; the combination of low serum PAPP\u2010A levels, maternal age, and elevated free \u03b2\u2010hCG levels yielded a detection rate of 78\u00b79 per cent (95 per cent CI 64\u00b79\u201392\u00b78 per cent) of the affected pregnancies at 8\u201312 weeks' gestation.<\/jats:p>","DOI":"10.1002\/pd.1970141106","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T07:05:42Z","timestamp":1172991942000},"page":"1043-1047","source":"Crossref","is-referenced-by-count":75,"title":["Serum PAPP\u2010A and free \u03b2\u2010hCG are first\u2010trimester screening markers for down syndrome"],"prefix":"10.1002","volume":"14","author":[{"given":"B.","family":"Brambati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tului","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bonacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shrimanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Grudzinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1802-2_12"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb12973.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/clinchem\/25.5.675","article-title":"Outliers in clinical chemistry quality control schemes","volume":"25","author":"Healy M. J. R.","year":"1979","journal-title":"Clin. Chem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970131004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130714"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/clinchem\/28.1.50","article-title":"Radioimmunoassay for pregnancy associated plasma protein A, PAPP\u2010A","volume":"28","author":"Sinosich M.","year":"1982","journal-title":"Clin. Chem."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92073-O"},{"key":"e_1_2_1_10_1","unstructured":"Van Lith J. M. M. Grudzinskas J. G. Mantingh A. Shrimanker K. Suzuki Y. Macintosh M. C. M.(1994). First trimester maternal serum PAPP\u2010A levels in pregnancies with chromosomally normal and abnormal fetuses Br. J. Obstet. Gynaecol. in press."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6844.28"},{"key":"e_1_2_1_12_1","unstructured":"Wright D. Donovan C. Davies C.(1993). Uncertainty in reported detection rates for Down syndrome screening: mathematical modelling techniques in obtaining confidence intervals 4th Conference of Endocrinology and Metabolism in Human Reproduction: Screening for Down's Syndrome London: RCOG Abstract 59 69."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970141106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970141106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:08:25Z","timestamp":1698131305000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970141106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1002\/pd.1970141106"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970141106","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}