{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:12:00Z","timestamp":1762521120003},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":4022,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypospadias is one of the most prominent and characteristic midline defects in male infants with the Wolf\u2010Hirschhorn (4p \u2014) syndrome. In this report we present a case in which hypospadias was identified prenatally at 29 weeks' gestation in association with intrauterine growth retardation. Cytogenetic evaluation after birth confirmed a 46, XY, del(4)(p14) karyotype. The prenatal identification of hypospadias in fetuses with intrauterine growth retardation and normal amniotic fluid should suggest a diagnosis of Wolf\u2010Hirschhorn syndrome.<\/jats:p>","DOI":"10.1002\/pd.1970141212","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:05:37Z","timestamp":1172973937000},"page":"1166-1169","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal detection of congenital hypospadias in the wolf\u2010hirschhorn (4p \u2014) syndrome"],"prefix":"10.1002","volume":"14","author":[{"given":"Fernando","family":"Vi\u00f1als","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldo","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Selman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1989.8.11.613"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310203091602"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.3.232"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1985.4.8.433"},{"key":"e_1_2_1_6_1","first-page":"1893","volume-title":"Campbell's Urology","author":"Duckett J. 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