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The diagnosis of <jats:italic>apparently<\/jats:italic> isolated agenesis of the corpus callosum (in the absence of other sonographically detectable anomalies) appears to carry an excellent prognosis, with an 85 per cent chance of a normal developmental outcome and a 15 per cent risk of handicap. Fetal karyotyping is recommended as there is a 1 in 10 risk of aneuploidy. If other anomalies are detected prenatally, the outcome is very poor. Termination of pregnancy is advised in these circumstances.<\/jats:p>","DOI":"10.1002\/pd.1970150402","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T11:05:35Z","timestamp":1173006335000},"page":"301-312","source":"Crossref","is-referenced-by-count":100,"title":["Assessment and management of fetal agenesis of the corpus callosum"],"prefix":"10.1002","volume":"15","author":[{"given":"Janesh K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lilford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1103","article-title":"Le syndrome des spasmes en flexion, ag\u00e9n\u00e9sie calleuse, anomalies chorior\u00e9tiniennes","volume":"26","author":"Aicardi J.","year":"1969","journal-title":"Arch. Fr. 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