{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:47:42Z","timestamp":1762865262787},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010two second\u2010trimester and eight third\u2010trimester (&gt;28\/40) autopsies with clinical or pathological evidence of oligohydramnios sequence (\u201cPotter's syndrome\u201d) were reviewed. Twenty\u2010eight cases had renal anomalies (71 per cent in terminations following prenatal ultrasound), 27 had no renal malformation (35 per cent with chorioamnionitis), and five had external assessments only. In 15 cases, the renal lesion was part of a multiple malformation syndrome. Seven cases had a lesion which either recurred in a sibling in the same family or was a recognized autosomal recessive syndrome. Three cases had an abnormal karyotype, two of which had renal anomalies. Maternal serum alpha\u2010fetoprotein (AFP) did not discriminate between cases with renal malformations and those without. Pulmonary hypoplasia was commoner in third\u2010trimester than in second\u2010trimester cases. External appearance and absent umbilical artery were not reliable predictors of underlying internal anomalies. These findings reflect the shift from postnatal to prenatal diagnosis in modern practice. In this series, mainly second\u2010trimester cases, 50 per cent of cases had no malformations, in a condition which is traditionally associated with renal disease. The high incidence of chorioamnionitis suggests that the mechanism of oligohydramnios is occult amniotic fluid leakage. Prenatal diagnosis of oligohydramnios in the second trimester is dependent on ultrasound scanning and a full post\u2010mortem examination is necessary to identify any underlying fetal cause.<\/jats:p>","DOI":"10.1002\/pd.1970150604","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T11:18:31Z","timestamp":1173007111000},"page":"519-525","source":"Crossref","is-referenced-by-count":12,"title":["Potter's syndrome in the second trimester\u2014prenatal screening and pathological findings in 60 cases of oligohydramnios sequence"],"prefix":"10.1002","volume":"15","author":[{"given":"R. J.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Goodburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","article-title":"Neonatal outcome after prolonged rupture of the membranes starting in the second trimester","volume":"1146","author":"Blott M.","year":"1988","journal-title":"Arch. Dis. Child."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(89)90187-1"},{"key":"e_1_2_1_4_1","first-page":"539","article-title":"Chorioamnionitis in the preterm gestation","volume":"59","author":"Garite T.","year":"1982","journal-title":"Obstet. 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