{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:18:55Z","timestamp":1775481535320,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The results of a prospective series of 1580 chorionic villus sampling (CVS) procedures using biopsy forceps are presented. Most of the procedures (1442), including 11 sets of twins, were performed by the transcervical approach (TC\u2010CVS), using a curved\u2010shank thin forceps, and 138 by the transabdominal approach (TA\u2010CVS), using a trocar\u2010guided straight thin forceps. The mean gestational age for TC\u2010CVS was 10.9 weeks, and in 233 cases (16 per cent) the procedure was carried out between the 12th and 14th weeks. The mean gestational age for TA\u2010CVS was 16.7 weeks. The major indication for CVS was advanced maternal age (92.7 per cent in the TC and 91.8 per cent in the TA approach), and indications for abnormal ultrasound findings were more common in the TA approach (4.5 per cent) than in TC\u2010CVS (0.07 per cent). Although sampling was apparently accomplished in all the procedures, in 3.1 per cent of the TC\u2010CVS and 2.2 per cent of TA\u2010CVS procedures, the samples were less than 1 mg after dissection. A cytogenic report was obtained in 96.1 per cent of the TC\u2010CVS and 90.6 per cent of the TA\u2010CVS. Maternal serum alpha\u2010fetoprotein (MSAFP) was measured before and after TC\u2010CVS and the post\u2010CVS MSAFP was positively correlated with the sample weight. Second\u2010trimester amniocentesis following CVS was required in 5.2 per cent (TC\u2010CVS) and 6.5 per cent (TA\u2010CVS), due to the failure to obtain a cytogenetic report or diagnostic confirmation. The follow\u2010up to the 20th week was 100 per cent by ultrasound scan, and 88.6 per cent from the 21st week to 1 week after delivery. Fetal loss rates within 2 weeks of the procedure were 1.7 per cent (TC\u2010CVS) and 0.8 per cent (TA\u2010CVS) and total fetal loss accumulated to 1 week after delivery was 4.6 per cent (TC\u2010CVS) and 5.9 per cent (TA\u2010CVS). Factors found to increase significantly fetal loss in the TC\u2010CVS series were maternal age and the collection of very small samples, but not the number of forceps insertions.<\/jats:p>","DOI":"10.1002\/pd.1970150607","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T11:18:31Z","timestamp":1173007111000},"page":"541-550","source":"Crossref","is-referenced-by-count":18,"title":["Chorionic villus sampling by biopsy forceps. Results of 1580 procedures from a single centre"],"prefix":"10.1002","volume":"15","author":[{"given":"A.","family":"Fortuny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Borrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Casals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Puerto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Seres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cararach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110810"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110503"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970111005"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140109"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91528-I"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3362-1_9"},{"key":"e_1_2_1_8_1","unstructured":"Fortuny A. Casals E. Soler A. Carrio A. Perez M. T. Costa D. Balmes I. Borrell A.(1990). Changes in maternal serum AFP after transcervical CVS by two different methods. In:European Society of Human Genetics Proc. Symposium 1990: Genetics in the 21st Century Corfu Greece 162."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091405"},{"key":"e_1_2_1_10_1","first-page":"23","article-title":"Genetic diagnosis in the embryo by means of biopsy from extraembryonic membranes","volume":"2","author":"Hahnemann N.","year":"1969","journal-title":"Bull. Eur. Soc. Hum. Genet."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93293-V"},{"key":"e_1_2_1_12_1","first-page":"512","volume-title":"Balliere's Clinical Obstetrics and Gynecology. Vol. 1. Fetal Diagnosis of Genetic Defects","author":"Jackson L. 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