{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:53Z","timestamp":1787235773710,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3757,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prenatal diagnosis performed by ultrasound scan is now a routine part of prenatal care in many countries. How many fetal anomalies are actually detected by these procedures? We have used our registry of congenital malformations to answer this question. In a previous study (\n                    <jats:italic>Prenat. Diagn.<\/jats:italic>\n                    ,\n                    <jats:bold>12<\/jats:bold>\n                    , 263\u2013270, 1992), considering the period 1979\u20131988, we have shown that prenatal diagnosis was performed in 23.1 per cent of fetuses with a chromosomal aberration and in 20.1 per cent of fetuses with non\u2010chromosomal anomalies. In 1991 and 1992, the percentatge of termination for Down syndrome was 44.4 and 41.9 per cent, respectively. From 1989 to 1992, the detection rate and the specificity of prenatal diagnosis by ultrasonographic examination were improved. The detection rate for isolated malformations (fetuses with only one anomaly) and for multiple malformed children was 26.2 and 66.0 per cent, respectively. The detection rate of congenital anomalies by ultrasonography was variable for the different categories of malformation. A high detection rate was observed for anencephaly (100 per cent) and urinary tract malformation. A low detection rate was seen for cleft lip (17.5 per cent) and limb reduction defects (18.2 per cent).\n                  <\/jats:p>","DOI":"10.1002\/pd.1970150902","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:11:45Z","timestamp":1172988705000},"page":"791-800","source":"Crossref","is-referenced-by-count":60,"title":["Evaluation of routine prenatal diagnosis by a registry of congenital anomalies"],"prefix":"10.1002","volume":"15","author":[{"given":"C.","family":"Stoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Alembik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Addor C. Marguerat P. H. Pescia G. Fokstuen S. Kovaliv P.(1994). Evaluation de l'efficacit\u00e9 du diagnostic pr\u00e9natal \u00e9chographique des malformations XIXe Journ\u00e9es du Club de Conseil G\u00e9n\u00e9tique de Langue Fran\u00e7aise Evian 15\u201317 September 1994."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.3.3685364"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071843"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970111205"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33043-5"},{"key":"e_1_2_1_7_1","unstructured":"Levi S. Hyjazi Y. Schaaps J. P. Defoort P. Coulon R. De Brier M.(1990). Sensitivity and specificity of antenatal screening for malformation by ultrasound. A multicentric study. Second European Symposium of the Prevention of Congenital Anomalies Ferrara Italy 28 September 1990 Abstract."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6840.1474"},{"issue":"1","key":"e_1_2_1_9_1","first-page":"1","article-title":"Evaluation of routine ultrasound examination for the prenatal diagnosis of malformation","volume":"2","author":"Lys F.","year":"1988","journal-title":"EUROCAT Newslett."},{"key":"e_1_2_1_10_1","first-page":"558","article-title":"Sonographic detection of fetal urinary\u2010tract anomalies","volume":"67","author":"Quinlan R. W.","year":"1986","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32241-4"},{"key":"e_1_2_1_12_1","volume-title":"Guide for Personal Computers","author":"Sas\/Stat TM","year":"1989"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(88)90005-6"},{"key":"e_1_2_1_14_1","first-page":"157","volume-title":"Prevention of Physical and Mental Congenital Defects","author":"Stoll C.","year":"1985"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00144842"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120405"},{"key":"e_1_2_1_17_1","unstructured":"Stoll C. Alembik Y. Dott B. Roth M. P.(1994a). Prevalence of neural tube defects in northeastern France from 1979 to 1992. Impact of prenatal diagnosis XIXe Journ\u00e9es du Club de Conseil G\u00e9n\u00e9tique de Langue Fran\u00e7aise Evian 15\u201317September 1994."},{"key":"e_1_2_1_18_1","first-page":"179","article-title":"Recent trends in the prevalence of Down syndrome in north\u2010eastern France","volume":"37","author":"Stoll C.","year":"1994","journal-title":"Ann. G\u00e9n\u00e9t."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90378-K"},{"key":"e_1_2_1_20_1","first-page":"640","article-title":"Antenatal evaluation and management of ultrasonically detected fetal anomalies","volume":"69","author":"Vintzileos A. M.","year":"1987","journal-title":"Obstet. 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