{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:09:31Z","timestamp":1782367771808,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3727,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied 201 pregnancies that were established by <jats:italic>in vitro<\/jats:italic> fertilization and embryo transfer (IVF\u2013ET) and compared the frequency of cytogenetic abnormalities with that found in a large control population matched for indication group (advanced maternal age) and time of sampling. A total of 252 IVF\u2013ET fetuses were cytogenetically analysed by either chorionic villus sampling (CVS; <jats:italic>n<\/jats:italic> = 80) or amniocentesis (<jats:italic>n<\/jats:italic> = 172). Eleven chromosome abnormalities were found in the CVS group (13\u00b78 per cent); among them, a 45, X\/46, X, dic(q11)\/46, X, del(Y)(q11) mosaic that was found in an IVF pregnancy established by intracytoplasmic sperm injection (ICSI), four cases of trisomy 21, and three cases of trisomy 7 confined to the placenta. The results indicate a statistically significant three\u2010to five\u2010fold increase in both confined placental abnormalities (<jats:italic>P<\/jats:italic>&lt;0\u00b7008) and true fetal chromosome anomalies (<jats:italic>P<\/jats:italic>&lt;0\u00b704). In the amniocentesis group, identical rates (1\u00b77 per cent) of chromosome abnormalities were found in the IVF\u2013ET and control groups. It is concluded that late first trimester, but not early second trimester, IVF\u2013ET pregnancies are characterized by an increased frequency of cytogenetic abnormalities found at prenatal diagnosis.<\/jats:p>","DOI":"10.1002\/pd.1970151014","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:13:45Z","timestamp":1173003225000},"page":"975-980","source":"Crossref","is-referenced-by-count":24,"title":["Increased incidence of cytogenetic abnormalities in chorionic villus samples from pregnancies established by <i>in vitro<\/i> fertilization and embryo transfer (IVF\u2013ET)"],"prefix":"10.1002","volume":"15","author":[{"given":"P. A. In't","family":"Veld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van Opstal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van Ooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Brandenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. J.","family":"Jahoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th.","family":"Stijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Los","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Assisted Conception Australia and New Zealand 1991","author":"AIHW National Perinatal Statistics Unit and Fertility Society of Australia","year":"1993"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1001\/jama.1992.03480130110034","article-title":"Congenital bilateral absence of the vas deferens: a primarily genital form of cystic fibrosis","volume":"267","author":"Anguiano A.","year":"1992","journal-title":"J. Am. Med. 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