{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:02:06Z","timestamp":1761742926765},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3696,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal urinary concentrations of insulin\u2010like growth factor I (UIGF\u2010I) and binding protein 3 (UIGFBP\u20103) were determined in patients with prenatal diagnosis of bilateral obstructive uropathy. Patients were retrospectively assigned to three groups, on the basis of outcome: group 1, termination of pregnancies (<jats:italic>n<\/jats:italic> = 11) with sonographic evidence of severe oligohydramnios or renal dysplasia, confirmed at histological examination; group 2, patients (<jats:italic>n<\/jats:italic> = 10) with postnatal plasma creatinine &gt; 50 \u03bcmol\/1 at the age of 1 year (1 yr\u2010pCreat); and group 3, patients (<jats:italic>n<\/jats:italic> = 16) with 1 yr\u2010pCreat \u2264 \u03bcmol\/1. The results show a significant increase in UIGF\u2010I and UIGFBP\u20103 in groups 1 (18 159 \u00b1 9083 pg\/ml; 2657 \u00b1 669 ng\/ml) and 2 (1574 \u00b1 847 pg\/ml; 176 \u00b1 50 ng\/ml) in comparison with group 3 (35 \u00b1 6 pg\/ml; 21 \u00b1 2 ng\/ml). UIGF\u2010I and UIGFBP\u20103 were significantly correlated with postnatal plasma creatinine, and were both sensitive (90 per cent; 80 per cent) and specific (88 per cent; 88 per cent) for prediction of elevated 1 yr\u2010pCreat (&gt;50 \u03bcmol\/1). Fetal urinary IGF\u2010I and IGFBP\u20103 are increased in severe fetal bilateral obstructive uropathy, possibly reflecting tubular dysfunction or\/and increased synthesis consequent upon fetal kidney injury. Their predictive value for postnatal renal function needs further assessment.<\/jats:p>","DOI":"10.1002\/pd.1970151110","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:10:50Z","timestamp":1173003050000},"page":"1047-1055","source":"Crossref","is-referenced-by-count":15,"title":["Fetal urinary insulin\u2010like growth factor I and binding protein 3 in bilateral obstructive uropathies"],"prefix":"10.1002","volume":"15","author":[{"given":"L.","family":"Bussieres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Laborde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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