{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:56:20Z","timestamp":1761101780869},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3666,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An i(Yp) is a rare marker chromosome. We present a case of <jats:italic>de novo<\/jats:italic> 46,X,i(Yp) detected prenatally in an amniotic fluid specimen. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) studies using a panel of Y\u2010specific biotinylated DNA probes identified the marker chromosome as i(Yp). Comparative genomic hybridization (CGH) studies further confirmed the diagnosis. Upon pregnancy termination, external examination of the fetus revealed a generally well\u2010developed male fetus with slight facial dysmorphism and prominent rocker\u2010bottom feet. The molecular cytogenetic data in this case proved very useful in genetic counselling and served as a good example illustrating the important role of molecular techniques for accurate identification of marker chromosomes.<\/jats:p>","DOI":"10.1002\/pd.1970151206","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:10:24Z","timestamp":1173003024000},"page":"1115-1119","source":"Crossref","is-referenced-by-count":16,"title":["Prenatal identification of i(YP) by molecular cytogenetic analysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Boris B. T.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loh\u2010Chung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willow","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena E.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"John","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90153-6"},{"key":"e_1_2_1_3_1","volume-title":"Diseases of the Fetus and Newborn","author":"Blair J. D.","year":"1995"},{"key":"e_1_2_1_4_1","first-page":"61","volume-title":"The Y Chromosome, Part B: Clinical Aspects of Y Chromosome Abnormalities","author":"Buhler E. M.","year":"1985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_1_6_1","first-page":"5","article-title":"A theory explaining the abnormality in 45,X\/46,XY mosaicism with non\u2010fluorescent Y chromosome\u2010presentation of three cases","volume":"21","author":"Kaluzewski B.","year":"1978","journal-title":"Ann. Genet."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221943"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.101.Supplement.151"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140105"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01876584"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130507"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970151206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970151206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T03:09:51Z","timestamp":1698289791000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970151206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1002\/pd.1970151206"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970151206","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}