{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:05:55Z","timestamp":1792166755416,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3666,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meckel\u2013Gruber syndrome is a rare autosomal recessive disorder often resulting in neonatal death within a few hours of life. The condition is usually diagnosed ultrasonographically in the second trimester and earlier diagnosis has been mainly confined to high recurrence risk pregnancies. We describe the earliest non\u2010invasive diagnosis of this condition at 12<jats:sup>+2<\/jats:sup> weeks' gestation in a patient with no previous history using transabdominal ultrasound. Pregnancy termination was declined. Subsequent development of anhydramnios in the mid\u2010trimester resulted in poor fetal visualization. We propose that first\u2010trimester diagnosis of this condition is not only possible but preferable, as normal liquor volume facilitates visualization of fetal anatomy.<\/jats:p>","DOI":"10.1002\/pd.1970151215","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:10:24Z","timestamp":1173003024000},"page":"1168-1170","source":"Crossref","is-referenced-by-count":25,"title":["First\u2010trimester diagnosis of Meckel\u2013Gruber syndrome by transabdominal sonography in a low\u2010risk case"],"prefix":"10.1002","volume":"15","author":[{"given":"Jeffrey M.","family":"Braithwaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios L.","family":"Economides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","unstructured":"Braithwaite J. M. Armstrong M. A. Economides D. L.(1995). The assessment of fetal anatomy at 12\u201313 weeks' gestation by trans\u2010abdominal and trans\u2010vaginal sonography.Br. J. Obset. Gynecol.(in press).","DOI":"10.1111\/j.1471-0528.1996.tb09520.x"},{"key":"e_1_2_1_3_1","first-page":"53","article-title":"Early prenatal diagnosis of Meckel syndrome\u2014a case report","volume":"46","author":"Cheng\u2010Juin Y.","year":"1990","journal-title":"Chin. Med. J."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140210"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1991.10.5.285"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90515-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320180416"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1990.9.12.691"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090307"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90797-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870200403"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970151215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970151215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T03:10:27Z","timestamp":1698289827000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970151215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1002\/pd.1970151215"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970151215","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}