{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:28:20Z","timestamp":1781789300009,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,4]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To evaluate associated congenital anomaly risk, need for surgical treatment and long\u2010term outcome in prenatally diagnosed clubfoot.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective study of 20 663 pregnant women who underwent routine ultrasound scanning at 18 to 22 weeks of gestation. Clubfoot was considered as complex<\/jats:italic> or isolated<\/jats:italic> if other structural or chromosomal abnormalities were also present or not.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010two cases of congenital clubfoot were diagnosed (incidence: 0.2%), 28 of them (66.6%) were isolated<\/jats:italic> and 14 (33.3%) were complex,<\/jats:italic> of which 3 (7.1%) had an abnormal karyotype and 11 (26.2%) had an associated structural anomaly. The false\u2010positive rate was 2.3% (1 out of 32 liveborns). Out of the 41 confirmed affected fetuses, the defect was unilateral in 12 (29.3%) and bilateral in 29 (70.7%) cases. Surgery was necessary in 12 of the newborns (38.7%). The presence of a bilateral clubfoot was unrelated to either the presence of associated anomalies (p<\/jats:italic> = 0.40) or to the necessity of surgery (p<\/jats:italic> = 0.48).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We provide outcome data about fetuses prenatally diagnosed for clubfoot. One\u2010third are complex<\/jats:italic> cases associated with other congenital anomalies. For isolated<\/jats:italic> clubfoot, the risk of requiring surgery is about 40%. The detection of a bilateral defect does not worsen the prognosis. Copyright \u00a9 2008 John Wiley & Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1984","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T13:17:11Z","timestamp":1206537431000},"page":"343-346","source":"Crossref","is-referenced-by-count":35,"title":["Prenatal diagnosis of clubfoot in low\u2010risk population: associated anomalies and long\u2010term outcome"],"prefix":"10.1002","volume":"28","author":[{"given":"M. J.","family":"Canto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Palau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00780.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199705)17:5<457::AID-PD86>3.0.CO;2-E"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B7.16076"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.00509.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-53"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1596"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980901)79:2<90::AID-AJMG3>3.0.CO;2-R"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00582-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-199605010-00011"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12020103.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70445-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B6.9777"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01241398-199901000-00003","article-title":"Prenatal sonographic diagnosis of clubfoot: implications for patients counselling","volume":"19","author":"Treadwell MC","year":"1999","journal-title":"J Pediatr Orthop"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1998.tb03071.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.5.321"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1984","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:24:00Z","timestamp":1700004240000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,26]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/pd.1984"],"URL":"https:\/\/doi.org\/10.1002\/pd.1984","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,26]]}}}