{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:49:46Z","timestamp":1766065786119},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T00:00:00Z","timestamp":1208995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leptin is a key regulator of satiety; and the serum concentration is considered to reflect nutritional status. Expressed predominantly by the adipocytes, leptin is also expressed in placenta, which is a major source of both leptin and the leptin receptor in pregnancy serum. As a placenta protein, leptin serum concentrations may be perturbed in Down syndrome (DS) pregnancies as seen for pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and human chorionic gonadotrophin\u2010\u03b2 (hCG\u03b2). We examined whether leptin is a maternal serum marker for foetal DS in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Serum samples from 44 pregnant women with a DS foetus, and 135 control pregnant women in week 8 to 14 had the leptin concentration determined by immunoassay and the concentrations were converted into multiples of the median (MoM) of controls based on log\u2010regression analysis. The distributions of log<jats:sub>10<\/jats:sub> MoM leptin was compared in DS and control pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum leptin increased significantly with gestational age in controls (<jats:italic>p<\/jats:italic> = 0.02). The mean log<jats:sub>10<\/jats:sub> MoM in controls was \u2212 0.0486, with a median empirical MoM of 0.89, and \u2212 0.0618, with a median empirical MoM of 0.80, in DS pregnancies. This difference was not significant. The log<jats:sub>10<\/jats:sub> MoM leptin values in DS pregnancies did not change with gestational age (<jats:italic>p<\/jats:italic> = 0.32).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leptin is not a first\u2010trimester marker for foetal DS. 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