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Cases should be referred <jats:italic>in utero<\/jats:italic> to tertiary care centers familiar with this condition both for prediction of outcome as well as timed delivery. The best validated prognostic indicator is the lung area to head circumference ratio. Ultrasound is used to measure the lung area of the index case, which is then expressed as a proportion of what is expected normally (observed\/expected LHR). When O\/E LHR is &lt; 25% survival chances are &lt; 15%. Prenatal intervention, aiming to stimulate lung growth, can be achieved by temporary fetal endoscopic tracheal occlusion (FETO). A balloon is percutaneously inserted into the trachea at 26\u201328 weeks, and reversal of occlusion is planned at 34 weeks. Growing experience has demonstrated the feasibility and safety of the technique with a survival rate of about 50%. The lung response to, and outcome after FETO, is dependent on pre\u2010existing lung size as well gestational age at birth. Early data show that FETO does not increase morbidity in survivors, when compared to historical controls. Several trials are currently under design. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.2033","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T14:42:34Z","timestamp":1216132954000},"page":"581-591","source":"Crossref","is-referenced-by-count":72,"title":["Prenatal diagnosis, prediction of outcome and <i>in utero<\/i> therapy of isolated congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"28","author":[{"given":"Elisa","family":"Don\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Gucciardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Van 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