{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:19:27Z","timestamp":1700651967261},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T00:00:00Z","timestamp":1221004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the utility of maternal serum ADAM12 as a Down's syndrome marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples from 71 Down's syndrome affected pregnancies were retrieved from \u2212 20 \u00b0C storage together with 710 controls matched for gestation and storage time. ADAM12 was measured prior to identification of the affected pregnancies, and expressed in multiples of the gestation\u2010specific median (MoM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median ADAM12 level in the affected pregnancies was 1.36 MoM with a 10th\u201390th centile range of 0.90\u20131.94 MoM compared with 1.01 and 0.65\u20131.52 MoM in the unaffected control pregnancies (<jats:italic>P<\/jats:italic> = &lt; 0.0001, two\u2010side Wilcoxon Rank Sum Test). The Mahalanobis distance between the medians was 0.96 compared with 0.92, 1.18, 1.07 and 1.24 for \u03b1\u2010fetoprotein, intact human chorionic gonadotrophin (hCG), unconjugated estriol and inhibin\u2010A respectively in the same samples. In unaffected pregnancies there were highly statistically significant correlations between ADAM12 and each of the other markers; in the affected pregnancies the only significant correlations were with hCG (<jats:italic>P<\/jats:italic>\u22640.0001) and inhibin\u2010A (<jats:italic>P<\/jats:italic>\u22640.05). Statistical modelling predicted that ADAM12 as a fifth marker could increase the detection rate by 2\u20133% or reduce the false\u2010positive rate by 0.9\u20131.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADAM12 is a second trimester marker of Down's syndrome, with discriminatory power similar to existing markers. It could be considered in multi\u2010marker combinations. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2043","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T12:17:11Z","timestamp":1221049031000},"page":"904-907","source":"Crossref","is-referenced-by-count":8,"title":["Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies"],"prefix":"10.1002","volume":"28","author":[{"given":"Kim","family":"Donalson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Wastell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Cuckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1750"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1665"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.990"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2005.05.004"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.762"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000165829.65319.65"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1480"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1540"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780110211"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T19:42:20Z","timestamp":1699990940000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/pd.2043"],"URL":"https:\/\/doi.org\/10.1002\/pd.2043","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,10]]}}}