{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:35:12Z","timestamp":1758926112406},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T00:00:00Z","timestamp":1216684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate whether cell\u2010free placental mRNA levels have the potential to predict a placenta previa resulting in hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight singleton pregnant women with placenta previa were classified into the following four groups: 16 women with placenta located at a posterior part of the uterine wall (Group A); 4 each with placenta located at the anterior wall without (Group B) or with (Group C) previous cesarean section; and the other 4 with a history of previous cesarean section and who had the placenta located at an anterior part of uterine wall and underwent a cesarean hysterectomy (Group D). The maternal plasma concentrations of the cell\u2010free placental lactogen (PL) mRNA measured by real\u2010time reverse\u2010transcription polymerase chain reaction (PCR) were converted into multiples of the median (MoM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MoM (range) values of cell\u2010free PL mRNA in the control group and Groups A to D were 1.00 (0.39\u20132.35), 2.04 (0.91\u20133.93), 2.58 (1.90\u20133.90), 3.50 (1.20\u20134.30), and 6.28 (5.24\u20137.63), respectively. The concentration of cell\u2010free PL mRNA was significantly higher in Group D than in Group A, B, or C (Mann\u2013Whitney's <jats:italic>U<\/jats:italic>\u2010test, <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The cell\u2010free PL mRNA concentration in maternal plasma has the potential to predict a subgroup of placenta accreta resulting in hysterectomy. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2056","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T10:24:35Z","timestamp":1216376675000},"page":"805-809","source":"Crossref","is-referenced-by-count":33,"title":["Increased level of cell\u2010free placental mRNA in a subgroup of placenta previa that needs hysterectomy"],"prefix":"10.1002","volume":"28","author":[{"given":"Kiyonori","family":"Miura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh\u2010ichiro","family":"Yoshiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Niikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Masuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1926"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.024"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.7.333"},{"key":"e_1_2_1_5_1","first-page":"266","article-title":"Placenta accreta is associated with elevated maternal serum alpha\u2010fetoprotein","volume":"82","author":"Kupferminc MJ","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1982"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30115"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.050666"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.047803"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.06.011"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.087890"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.5.727"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0637450100"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000207559.15715.98"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.081372"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.2.353"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.041"},{"key":"e_1_2_1_18_1","first-page":"693","article-title":"Placenta accreta\/percreta\/increta: a cause of elevated maternal serum alpha\u2010fetoprotein","volume":"80","author":"Zelop C","year":"1992","journal-title":"Obstet Gynecol"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2056","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T07:33:08Z","timestamp":1700033588000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,22]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/pd.2056"],"URL":"https:\/\/doi.org\/10.1002\/pd.2056","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,22]]}}}