{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:12:30Z","timestamp":1780092750187,"version":"3.54.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T00:00:00Z","timestamp":1226275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the practices of parents of beta thalassaemia children towards utilization of prenatal diagnosis (PND) in Pakistan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was done between April and September 2007 at two thalassaemia treatment centers in Rawalpindi and Islamabad. Simple random sampling was employed to interview 215 parents of thalassaemic children. Parents of thalassaemic children who were not planning to have any more children were excluded from the study. A structured questionnaire with preassigned values was developed for collection of data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 215 respondents, 149 (69%) families had a pregnancy following the birth of the registered thalassaemic child. Among 149 couples, 90 (60%) did not request PND. The main reasons for underutilization of PND included lack of awareness (23%), high cost (23%), poor access (17%), delay in seeking (16%) and advice against the test (12%). A significant improvement in the use of PND was observed with increasing mother's education (<jats:italic>p<\/jats:italic> &lt; 0.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PND for thalassaemia is available in Pakistan for over a decade but its use remains limited. There is a need to increase its utilization by addressing various impediments noted in this study. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2133","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T11:38:18Z","timestamp":1226317098000},"page":"1116-1118","source":"Crossref","is-referenced-by-count":7,"title":["Impediments to prenatal diagnosis for beta thalassaemia: experiences from Pakistan"],"prefix":"10.1002","volume":"28","author":[{"given":"Sajida","family":"Naseem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhaib","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhaan","family":"Vahidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,10]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"AhmedS.1998. An approach for the prevention of thalassaemia in Pakistan. PhD thesis London: University College London Medical School."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065167"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<378::AID-PD815>3.0.CO;2-7"},{"key":"e_1_2_1_5_1","unstructured":"AlwanAA ModellB.1997.Community control of genetic and congenital disorders EMRO Technical Publication Series 24. WHO Regional Office for the Eastern Mediterranean Region ISBN 92\u20109021\u2010220\u20109ISSN 1020."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000162191.22091.e9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.5.061903.175935"},{"key":"e_1_2_1_8_1","first-page":"9","article-title":"Implications of prenatal diagnosis of sickle cell disease","volume":"7","author":"De Montalambert M","year":"1996","journal-title":"Genet Couns"},{"issue":"1","key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.26719\/1997.3.1.123","article-title":"Genetic disorders and congenital abnormalities: strategies for reducing the burden in the Region","volume":"3","author":"Hamamy H","year":"1997","journal-title":"East Mediterr Health J"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2004.04.003"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723098"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:27:46Z","timestamp":1699961266000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,10]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1002\/pd.2133"],"URL":"https:\/\/doi.org\/10.1002\/pd.2133","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,10]]}}}