{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:21:09Z","timestamp":1774264869878,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2001,12,3]],"date-time":"2001-12-03T00:00:00Z","timestamp":1007337600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on ten pregnancies with trisomy 8 mosaicism. Nine cases were prenatally detected in chorionic villi (<jats:italic>n<\/jats:italic>=6), amniotic fluid (AF) cells (<jats:italic>n<\/jats:italic>=2) or fetal blood (FB) lymphocytes (<jats:italic>n<\/jats:italic>=1). Follow\u2010up laboratory investigations showed confined placental mosaicism (CPM) or pseudomosaicism in eight cases. In one case with ultrasound abnormalities, trisomy 8 mosaicism was detected in FB cells although cultured AF cells showed normal cells only. Another case of mosaic trisomy 8 was prenatally missed; cytogenetic analysis of short\u2010term cultured villi revealed a normal male karyotype, while postnatally, trisomy 8 mosaicism was detected in peripheral blood lymphocytes and skin fibroblasts of the affected child.<\/jats:p><jats:p>These findings indicate the difficulties in the prenatal diagnosis of trisomy 8 mosaicism. When found in chorionic villi, it mostly represented CPM, while in a case of true fetal trisomy 8 mosaicism, the cytotrophoblast cells showed a normal karyotype. So, the cytotrophoblast compartment of chorionic villi is a poor indicator of the presence or absence of fetal trisomy 8 mosaicism. Follow\u2010up investigations including amniocentesis and especially fetal blood sampling are required to come to a definite prenatal diagnosis of trisomy 8 mosaicism. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.215","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:24:03Z","timestamp":1030292643000},"page":"1075-1078","source":"Crossref","is-referenced-by-count":35,"title":["Management of prenatally detected trisomy 8 mosaicism"],"prefix":"10.1002","volume":"21","author":[{"given":"M. M.","family":"van Haelst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Van Opstal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Lindhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Los","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110111"},{"key":"e_1_2_1_3_1","first-page":"A196","article-title":"Alpha satellite\u2010like sequences at the centromere of chromosome #8","volume":"39","author":"Donlon T","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070505"},{"key":"e_1_2_1_5_1","first-page":"69","article-title":"Etude en fluorescence d'une trisomie C mosaique probablement 8: 46,XY\/ 47, XY,?8+","volume":"14","author":"De Grouchy JC","year":"1971","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150815"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151222"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<801::AID-PD153>3.0.CO;2-E"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02281877"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120702"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1081::AID-PD682>3.0.CO;2-Z"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02185754"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867735"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200212"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140606"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120503"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212016"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(1998100)18:10<1023::AID-PD402>3.0.CO;2-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_2_1_20_1","first-page":"197","volume-title":"New Chromosomal Syndromes","author":"Pfeiffer RA","year":"1977"},{"key":"e_1_2_1_21_1","first-page":"917","article-title":"Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction","volume":"60","author":"Robinson WP","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140728"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130803"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970090503"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199710)17:10<933::AID-PD179>3.0.CO;2-0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200012)20:12<956::AID-PD956>3.0.CO;2-Y"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91565-4"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200102)21:2<75::AID-PD990>3.0.CO;2-B"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199807)18:7<737::AID-PD326>3.0.CO;2-T"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<511::AID-PD904>3.0.CO;2-8"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:52:07Z","timestamp":1700322727000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/pd.215"],"URL":"https:\/\/doi.org\/10.1002\/pd.215","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}