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The anatomic descriptions are limited to details that are of interest for the understanding of ultrasound examinations. Further, the detection of main CNS anomalies including spina bifida during the first trimester are presented and discussed. Empty or enlarged brain cavities, or abnormal contours of the head and spine are important diagnostic markers for the detection of CNS anomalies in the very early pregnancy. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.2170","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T14:33:45Z","timestamp":1233758025000},"page":"312-325","source":"Crossref","is-referenced-by-count":107,"title":["Sonoembryology and early prenatal diagnosis of neural anomalies"],"prefix":"10.1002","volume":"29","author":[{"given":"H.\u2010G. K.","family":"Blaas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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