{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:57:53Z","timestamp":1761580673507},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T00:00:00Z","timestamp":1237248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate whether amnniocentesis in the second trimester is associated with congenital talipes equinovarus (CTEV) in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2010control study nested within a population\u2010based cohort, developed through linkage of the Scottish Congenital Anomalies Linked Database with records of amniocentesis from cytogenetics laboratories, including 564 299 singleton births 1992\u20132001. Odds ratios and 95% confidence intervals for CTEV in the offspring (isolated, non\u2010isolated, total) were calculated using logistic regression, adjusting for maternal age, year of birth and health board of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a modest positive association between total CTEV and amniocentesis at any time (OR = 1.27, 95% CI 0.99\u20131.65) and at \u2265 15 weeks (OR = 1.25, 95%CI 0.95\u20131.64). The association was strongest for non\u2010isolated CTEV (amniocentesis any time: OR = 1.68, 95%CI 1.08\u20132.61; amniocentesis \u2265 15 weeks: OR = 1.81, 95%CI 1.16\u20132.83). Amniocentesis at \u2265 20 weeks was associated with increased risk of total (OR = 5.87, 95% CI 3.38\u201310.21), non\u2010isolated (OR = 13.17, 95% CI 6.49\u201326.74) and isolated CTEV (OR = 3.10, 95% CI 1.28\u20137.49). There were no associations in mothers aged \u2265 35 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The modest association observed is most likely accounted for by amniocenteses conducted because of an earlier abnormal prenatal test. Thus, second trimester amniocentesis is unlikely to contribute to the development of CTEV in the offspring. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2233","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T15:20:02Z","timestamp":1237303202000},"page":"613-619","source":"Crossref","is-referenced-by-count":5,"title":["Amniocentesis in the second trimester and congenital talipes equinovarus in the offspring: a population\u2010based record linkage study in Scotland"],"prefix":"10.1002","volume":"29","author":[{"given":"A. 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