{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:39Z","timestamp":1786978299429,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wetenschappelijk Onderzoek Vlaanderen","award":["G.0378.02"],"award-info":[{"award-number":["G.0378.02"]}]},{"name":"Wetenschappelijk Onderzoek Vlaanderen","award":["G.0230.05N"],"award-info":[{"award-number":["G.0230.05N"]}]},{"name":"European Commission EuroSTEC","award":["LSHC-CT-2006-037409"],"award-info":[{"award-number":["LSHC-CT-2006-037409"]}]},{"name":"Flemish government via","award":["IWT-070715"],"award-info":[{"award-number":["IWT-070715"]}]},{"name":"Fundamental Clinical Researcher","award":["1801207"],"award-info":[{"award-number":["1801207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We studied the vascular effects of betamethasone (BM) and\/or tracheal occlusion (TO) in fetal rabbits with surgically induced congenital diaphragmatic hernia (CDH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      At day 23 (pseudoglandular phase; term = 31 d), 54 ovarian\u2010end fetuses from 27 does underwent induction of CDH. Thirteen did receive either 0.05 mg\/kg BM, on days 28 and 29 with a 24\u2010h interval, or 14 saline [controls (CTR)]. At day 28, one ovarian\u2010end fetus underwent TO and harvesting was at term. In total, we compared (ANOVA) lung\u2010to\u2010body weight ratio (LBWR) and vascular morphometric indices in survivors from the following groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2010 number alive at delivery): CDH (9); CDH + TO (10); unoperated controls (14); CDH + BM (10); CDH + TO (9); controls CTR + BM (13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Maternal BM had no effect on LBWR. LBWR was comparable to normal in CDH fetuses undergoing TO. Both TO and BM have an effect on medial thickening due to CDH which is larger when both interventions are combined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both TO and BM lessen peripheric muscularization present in CDH lungs and their effect is cumulative. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.2243","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T05:53:08Z","timestamp":1239688388000},"page":"674-681","source":"Crossref","is-referenced-by-count":14,"title":["The effect of maternal betamethasone and fetal tracheal occlusion on pulmonary vascular morphometry in fetal rabbits with surgically induced diaphragmatic hernia: a placebo controlled morphologic study"],"prefix":"10.1002","volume":"29","author":[{"given":"Xenia I.","family":"Roubliova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Lewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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