{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:08:59Z","timestamp":1790694539124,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T00:00:00Z","timestamp":1238371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The suspicion of an abnormality of the central nervous (CNS) system raises difficult questions for the clinician and the family and will inevitably lead to considerable anxiety. These questions include what it means for the child's future, whether it can be treated and whether it will happen again in subsequent pregnancies. For many disorders accurate prenatal diagnosis remains elusive, as even with fetal magnetic resonance imaging (MRI), early recognition and characterisation are simply not possible because of the immature state of brain development at that stage of pregnancy. The natural history of many prenatally diagnosed CNS disorders remains to be elucidated which means that an accurate prognosis cannot be given in all cases. We review the current state of knowledge regarding the investigation, management and prognosis of the most common and important CNS malformations. We also discuss the post\u2010natal management of these conditions both in the neonate and subsequent pregnancies for the families. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.2245","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T20:05:04Z","timestamp":1238443504000},"page":"442-449","source":"Crossref","is-referenced-by-count":22,"title":["Post\u2010natal investigations: management and prognosis for fetuses with CNS anomalies identified <i>in utero<\/i> excluding neurosurgical problems"],"prefix":"10.1002","volume":"29","author":[{"given":"Amal S.","family":"Mighell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed D.","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Levene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.008"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1135"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086806"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.37939.570104.EE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7340.761"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00688.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10258"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960823)64:3<465::AID-AJMG4>3.0.CO;2-O"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90340-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30862"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127463"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00173-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2006.00602.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1991.tb14813.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2006.02208.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1719"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1857"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.100"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053898"},{"issue":"4","key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/jmf.10.4.258.263","article-title":"The degree of antenatal ventriculomegaly is related to pediatric neurological morbidity","volume":"10","author":"Graham E","year":"2001","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.1.26"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-001-0719-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1827"},{"issue":"5","key":"e_1_2_1_25_1","first-page":"267","article-title":"Agenesis of the corpus callosum: lessons from humans and mice","volume":"28","author":"Kamnasaran D","year":"2005","journal-title":"Clin Invest Med"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1993.tb04443.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500329775"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00385.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2006.06.016"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01050.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1427"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.01.026"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00299008"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2118-8"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.09040229.x"},{"issue":"25","key":"e_1_2_1_36_1","first-page":"404","article-title":"The prognosis of agenesis of the corpus callosum might mostly be favourable","volume":"136","author":"Ramelli GP","year":"2006","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-357"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-1073-1"},{"key":"e_1_2_1_39_1","volume-title":"Fetal and Neonatal Neuriology and Neurosurgery","author":"Suri M","year":"2008"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7455683"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1240"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2774"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:54:44Z","timestamp":1694652884000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,30]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/pd.2245"],"URL":"https:\/\/doi.org\/10.1002\/pd.2245","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,30]]}}}