{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:32Z","timestamp":1787314172180,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the alterations of mRNA expressions associated with oxidative stress in the cellular component of blood from pregnant women with pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Peripheral blood samples were obtained from pregnant women with and without pre\u2010eclampsia. Cellular RNA was subjected to a reverse transcription polymerase chain reaction (PCR) assay in order to examine the mRNA distribution among women with pre\u2010eclampsia (\n                      <jats:italic>n<\/jats:italic>\n                      = 24) and control subjects (\n                      <jats:italic>n<\/jats:italic>\n                      = 24) during 35\u201341 weeks of gestation. The data were analyzed by non\u2010parametric statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant differences between the pre\u2010eclampsia subjects and the controls were observed in the gene expressions associated with oxidative stress. Lower values in the pre\u2010eclampsia group were found for heme oxygenase (HO)\u20101, HO\u20102, catalase and superoxide dismutase (SOD). The HO\u20101, HO\u20102 and the catalase levels significantly correlated with proteinuria, and the HO\u20102 level with systolic blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significantly lower concentrations of HO\u20101, HO\u20102, SOD and catalase are found in the cellular component of blood from pre\u2010eclamptic patients. The values correlate with the severity of pre\u2010eclampsia. These findings indicate that enhanced oxidative stress and a decrease in the number of anti\u2010oxidant enzymes may be associated with pre\u2010eclampsia. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.2278","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T19:23:52Z","timestamp":1240860232000},"page":"691-696","source":"Crossref","is-referenced-by-count":43,"title":["Cellular mRNA expressions of anti\u2010oxidant factors in the blood of preeclamptic women"],"prefix":"10.1002","volume":"29","author":[{"given":"Masamitsu","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuditiya","family":"Purwosunu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noroyono","family":"Wibowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401783"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.660134"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0809"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2109"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1562"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64849-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055352"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.05.004"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000286761.11436.67"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.040634"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.11.1832"},{"key":"e_1_2_1_15_1","first-page":"e1","article-title":"Evaluation of physiological alterations of the placenta through analysis of cell\u2010free mRNA concentrations of angiogenic factors","volume":"124","author":"Purwosunu Y","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1780"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.081372"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1429"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2005.10.001"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.09.011"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2278","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T04:17:24Z","timestamp":1696652244000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,27]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/pd.2278"],"URL":"https:\/\/doi.org\/10.1002\/pd.2278","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,27]]}}}