{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:39:41Z","timestamp":1772969981928,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T00:00:00Z","timestamp":1240790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Achondroplasia is one of the most common forms of short limb dwarfism. It is usually suspected on third trimester routine ultrasound because of very shortened long bones. We have described two new prenatal sonographic signs of achondroplasia visible at the proximal femoral metaphysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over 5 years, five fetuses were diagnosed with achondroplasia at the Grenoble Prenatal Diagnosis Centre. Ultrasound and tomographic examinations were performed by specialists. To study the proximal metaphysis, the ultrasound transducer was positioned at a 45 degree angle to the diaphyseal axis. Postnatal diagnosis was confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On computed tomography and postnatal X\u2010ray, proximal femoral metaphysis appeared rounded, with poor, uneven ossification. Connexion to diaphysis was abnormal, with relative overgrowth of the periosteum, creating a new diagnostic sign that we called the \u2018collar hoop\u2019 sign. On ultrasound, all fetuses had a very rounded metaphyseal\u2013epiphyseal interface, with an angle connexion to diaphysis wider than expected. The \u2018collar hoop\u2019 sign was obvious on four of the fetuses. During the same period, proximal femoral metaphyses appeared normal in 653 healthy fetuses, suggesting high specificity of those two new signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metaphysis examination is recommended if fetal femur length measures below the fifth percentile, as normal aspect may rule out achondroplasia. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2280","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T23:23:19Z","timestamp":1240874599000},"page":"697-702","source":"Crossref","is-referenced-by-count":39,"title":["Prenatal diagnosis of achondroplasia: new specific signs"],"prefix":"10.1002","volume":"29","author":[{"given":"St\u00e9phanie","family":"Boulet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Althuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Nugues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Patrick","family":"Schaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Simon","family":"Jouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.12.008"},{"issue":"1","key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2106\/00004623-195840010-00015","article-title":"Electron microscopy of epiphyseal and articular cartilage matrix in the femur of the newborn infant","volume":"40","author":"Cameron DA","year":"1958","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3995(00)01026-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199804)18:4<357::AID-PD276>3.0.CO;2-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61090-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.111"},{"issue":"3","key":"e_1_2_1_8_1","first-page":"185","article-title":"Bone dysplasia series. 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