{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:45Z","timestamp":1788871785116,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,18]],"date-time":"2010-03-18T00:00:00Z","timestamp":1268870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PerkinElmer Life and Analytical Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2010,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To examine placental growth factor (PlGF) levels in first trimester maternal serum in trisomy 21 pregnancies and to investigate the potential value of PlGF in a first trimester screening test.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n First trimester maternal serum from 70 trisomy 21 cases and 375 euploid controls were retrospectively analyzed for PlGF using a DELFIA\n \u00ae<\/jats:sup>\n Xpress immunoassay platform. Results were expressed as multiples of medians (MoM) for comparison.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n PlGF levels were significantly decreased in pregnancies with trisomy 21, 0.76 MoM versus 0.98 MoM in controls. Inclusion of PlGF into the first trimester combined test [maternal age, pregnancy associated plasma protein\u2010A (PAPP\u2010A), free\u2010\u03b2 human chorionic gonadotrophin (\u03b2\u2010hCG) and nuchal translucency] would increase the detection rate by 0.5% at a 5% false positive rate.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PlGF at 11 weeks to 13 weeks 6 days has the potential to be included as a marker for the detection of pregnancies with trisomy 21. Copyright \u00a9 2010 John Wiley & Sons, Ltd.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pd.2496","type":"journal-article","created":{"date-parts":[[2010,3,20]],"date-time":"2010-03-20T18:51:38Z","timestamp":1269111098000},"page":"449-453","source":"Crossref","is-referenced-by-count":20,"title":["First trimester maternal serum placental growth factor in trisomy 21 pregnancies"],"prefix":"10.1002","volume":"30","author":[{"given":"N. 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