{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:28Z","timestamp":1786978288025,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T00:00:00Z","timestamp":1272931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the National Institute on Aging"},{"name":"NIH","award":["HD41404"],"award-info":[{"award-number":["HD41404"]}]},{"name":"NIH","award":["048862"],"award-info":[{"award-number":["048862"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Placenta\u2010specific 1 (\n                    <jats:italic>PLAC1<\/jats:italic>\n                    ) is a recently described X\u2010linked gene with expression restricted primarily to cells derived from trophoblast lineage during embryonic development.\n                    <jats:italic>PLAC1<\/jats:italic>\n                    localizes to a region of the X chromosome thought to be important in placental development although its role in this process has not been defined. This review summarizes our current understanding of its expression, regulation, and function.\n                    <jats:italic>PLAC1<\/jats:italic>\n                    is expressed throughout human pregnancy by the differentiated trophoblast and localizes to membranous structures in the syncytiotrophoblast, including the microvillous plasma membrane surface. Recent studies have demonstrated that\n                    <jats:italic>PLAC1<\/jats:italic>\n                    is also expressed by a wide variety of human cancers. Studies of the\n                    <jats:italic>PLAC1<\/jats:italic>\n                    promoter regions indicate that its expression in both normal placenta and cancer cells is driven by specific interactions involving a combination of transcription factors. Although functional insight into PLAC1 in the normal trophoblast is lacking, preliminary studies suggest that cancer\u2010derived PLAC1 has the potential to promote tumor growth and function. In addition, it also appears to elicit a specific immunologic response that may influence survival in some cancer patients, suggesting that it may provide a therapeutic target for the treatment of some cancers. We also discuss a potential role for PLAC1 as a biomarker predictive of specific pregnancy complications, such as preeclampsia. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/pd.2506","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T18:26:46Z","timestamp":1272997606000},"page":"497-502","source":"Crossref","is-referenced-by-count":46,"title":["PLAC1 (Placenta\u2010specific 1): a novel, X\u2010linked gene with roles in reproductive and cancer biology"],"prefix":"10.1002","volume":"30","author":[{"given":"Michael","family":"Fant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaiah","family":"Nagaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schlessinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11995"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80853-9"},{"key":"e_1_2_1_4_1","first-page":"124","article-title":"PLAC1\/CP1 gene expression and autologous humoral immunity in gastric cancer patients","volume":"38","author":"Chen J","year":"2006","journal-title":"Beijing Da Xue Xue Bao"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6302"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081365"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65123-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23341"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.10200"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20673"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.041228"},{"key":"e_1_2_1_12_1","first-page":"9","article-title":"Increased plasma mRNAs of placenta\u2010 specific 1 (PLAC1) and glial cells\u2010missing 1 (GCM1) in mothers with pre\u2010eclampsia","volume":"55","author":"Fujito N","year":"2006","journal-title":"Hiroshima J Med Sci"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/153.1.383"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0777"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb802"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401600101"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-7-11"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.12.1967"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1350"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","unstructured":"KoslowskiM TuereciO BiesterfeldS et al.2009.Selective activation of trophoblast\u2010specific PLAC1 in breast cancer by CCAAT\/enhancer binding protein \u03b2 (C\/EBP\u03b2) isoform 2 JBC August 3 2009\u2014E published.","DOI":"10.1074\/jbc.M109.031120"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21222"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900747"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.12.2141"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.029"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20272"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.5.727"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.11.1832"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1780"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.11.016"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.1.1"},{"key":"e_1_2_1_31_1","first-page":"18","article-title":"PLAC1, a trophoblast\u2010specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses","volume":"7","author":"Silva WA","year":"2007","journal-title":"Cancer Immunol"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0870"},{"key":"e_1_2_1_33_1","first-page":"6","article-title":"Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer","volume":"9","author":"Tchabo NE","year":"2009","journal-title":"Cancer Immunol"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10010"},{"key":"e_1_2_1_35_1","unstructured":"YinQ FantM FlemingtonE. (Abstract 6.011). The Placenta Specific Gene PLAC1 is induced by the Epstein\u2010Barr Virus and is expressed in human tumor cells. 12thBiennial Conference of the International Association for Research on Epstein\u2010Barr Virus and Associated Diseases. 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