{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:55:26Z","timestamp":1791176126369,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018Contrat d\u2019Inititation \u00e0 la Recherche Clinique","award":["CRC03120"],"award-info":[{"award-number":["CRC03120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detailed indications for TOPFA were extracted from medical charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2465 completed records, indications were: chromosomal anomalies <jats:italic>n<\/jats:italic> = 963 (39.1%), malformations of a single organ without chromosomal or genetic aetiologies <jats:italic>n<\/jats:italic> = 898 (36.4%), multiple malformations without chromosomal or genetic aetiologies <jats:italic>n<\/jats:italic> = 238 (9.7%), obstetrical complications <jats:italic>n<\/jats:italic> = 161 (6.5%), non\u2010chromosomal genetic diseases <jats:italic>n<\/jats:italic> = 158 (6.4%), foetal infections <jats:italic>n<\/jats:italic> = 21 (0.9%), unexplained severe oligohydramnios <jats:italic>n<\/jats:italic> = 20 (0.8%), foetal exposure to teratogenic agents <jats:italic>n<\/jats:italic> = 6. Overall, 33.3% of anomalies were lethal (e.g. anencephaly), 25.2% were expected to result in isolated mental retardation (e.g. Down) and 35.1% in substantial handicap (e.g. myelomeningocele). In 6.4% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although there is no indisputable definition of which anomalies are \u2018severe\u2019, 93.6% of the decisions to terminate the pregnancy were made by women and professionals in reaction to anomalies which clearly were lethal or would lead to substantial physical and\/or mental disabilities. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2510","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T05:20:44Z","timestamp":1273123244000},"page":"531-539","source":"Crossref","is-referenced-by-count":68,"title":["Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?"],"prefix":"10.1002","volume":"30","author":[{"given":"Marc","family":"Dommergues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mandelbrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mahieu\u2010Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Boudjema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Durand\u2010Zaleski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the ICI Group\u2010Club de m\u00e9decine foetale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.04.004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01700.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.OGX.0000071485.75220.AE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08265.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200781"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1784"},{"key":"e_1_2_1_8_1","unstructured":"http:\/\/www.agence\u2010biomedecine.fr\/fr\/doc\/rapp\u2010synth2007.pdf[2009]."},{"key":"e_1_2_1_9_1","unstructured":"http:\/\/www.dh.gov.uk\/en\/Publicationsandstatistics\/Publications\/PublicationsStatistics\/DH_4136852[June 2007]."},{"key":"e_1_2_1_10_1","unstructured":"http:\/\/www.eurocat.ulster.ac.uk\/pdf\/EUROCAT\u2010Final\u2010EC\u2010Report.pdf[5 May 2009]."},{"key":"e_1_2_1_11_1","unstructured":"http:\/\/www.healthindicators.org[2009]."},{"key":"e_1_2_1_12_1","unstructured":"International Planned Parenthood Federation.IPPF European Network. Abortion Legislation in Europe. Brussels Jan 2007 IPPF European Network:info@ippfen.org."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01794.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.069377"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00117.x"},{"key":"e_1_2_1_16_1","unstructured":"Loi n\u00b0 45\u201017 du 17 janvier.1975."},{"key":"e_1_2_1_17_1","unstructured":"Loi n\u00b0 2001\u2010588 du 4 juillet.2001."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199909)19:9<808::AID-PD637>3.0.CO;2-B"},{"key":"e_1_2_1_19_1","first-page":"52","article-title":"Determinants of parental decision to abort or continue after non\u2010aneuploid ultrasound\u2010detected foetal abnormalities","volume":"80","author":"Pryde PG","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jme.27.3.165"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01673-8"},{"key":"e_1_2_1_22_1","unstructured":"SicardD.La France au risque de l'eug\u00e9nisme.2007.www.lemoned.fr|03.02.07|12h33 updated 03.02.07|20h23."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01279.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:42:29Z","timestamp":1700649749000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,21]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/pd.2510"],"URL":"https:\/\/doi.org\/10.1002\/pd.2510","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,21]]}}}