{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:59:33Z","timestamp":1759564773834},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,2,14]],"date-time":"2002-02-14T00:00:00Z","timestamp":1013644800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Angiotensin\u2010converting enzyme (ACE), a component of the renin\u2013angiotensin system (RAS), catalyses the degradation of angiotensin I to angiotensin II. It was the aim of the present study to measure ACE activity in human fetal blood and to determine its changes with advancing gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal blood was sampled by cordocentesis from six control fetuses and six fetuses with Rh isoimmunisation. Cord blood was sampled from six preterm neonates, 15 neonates after spontaneous delivery at term and six neonates at term after caesarean section. In addition, maternal ACE values were determined. ACE activity was measured using the miniaturised fluorimetric method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal fetuses (13.31\u00b11.41\u2009nmol HL\/min\/ml) and fetuses with Rh isoimmunisation (13.08\u00b12.00\u2009nmol HL\/min\/ml) ACE activity was significantly higher than in corresponding maternal plasma (10.39\u00b10.93\u2009nmol HL\/min\/ml, <jats:italic>p<\/jats:italic>&lt;0.05). Neonatal cord blood of preterm newborns (10.43\u00b10.69\u2009nmol HL\/min\/ml) and term newborns (8.99\u00b10.49\u2009nmol HL\/min\/ml) showed a significantly decreased ACE activity compared to the fetal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the high fetal ACE activity and the stringent regulation with advancing gestational age indicate the physiological importance of the enzyme during prenatal development. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.254","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T01:59:00Z","timestamp":1031709540000},"page":"111-113","source":"Crossref","is-referenced-by-count":15,"title":["Fetal, neonatal cord, and maternal plasma concentrations of angiotensin\u2010converting enzyme (ACE)"],"prefix":"10.1002","volume":"22","author":[{"given":"Thomas","family":"Walther","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaldo","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Maul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz\u2010Peter","family":"Schultheiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010E.","family":"Siems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Stepan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241100"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD98101"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.2.416"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80081-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1981.tb01198.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-3-434"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000293738"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1542\/peds.58.4.484","article-title":"Cardiorespiratory status of erythroblastic newborn infants: III. Intravascular pressures during the first hours of life","volume":"58","author":"Phibbs RH","year":"1976","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_1","first-page":"449","article-title":"Factors affecting angiotensin II concentrations in the human infant at birth","volume":"52","author":"Pipkin FB","year":"1977","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018032"},{"key":"e_1_2_1_12_1","first-page":"E237","article-title":"Comparison of ANG II in fetal and pregnant sheep: metabolic clearance and vascular sensitivity","volume":"268","author":"Rosenfeld CR","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_13_1","first-page":"2067","article-title":"Early expression of all the components of the renin\u2010angiotensin\u2010system in human development","volume":"149","author":"Schutz S","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb06760.x"},{"key":"e_1_2_1_15_1","first-page":"453","article-title":"Expression of angiotensin\u2010converting enzyme in human placenta and its physiologic role in the fetal circulation","volume":"84","author":"Yagami H","year":"1994","journal-title":"Obstet Gynecol"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:52:44Z","timestamp":1700308364000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1002\/pd.254"],"URL":"https:\/\/doi.org\/10.1002\/pd.254","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}