{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:43:12Z","timestamp":1698770592246},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the extent of fetal structural abnormalities, other than neural tube and abdominal wall defects (AWDs), identified by California's Prenatal Screening Program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Quad Marker Prenatal Screening records of 516,172 women were examined for screening interpretation and the diagnosis of structural abnormalities detected via follow\u2010up. Women who were screen\u2010positive for trisomy 21, trisomy 18, neural tube defects (NTDs) or Smith\u2010Lemli\u2010Opitz syndrome (SLOS) received follow\u2010up services at state\u2010approved Prenatal Diagnosis Centers (PDCs). Detailed reports of services and diagnostic information were linked in a database to the original screening results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 323 women received follow\u2010up ultrasound services at the PDCs in the study time period. Of these women, 1085 (4.1%) were identified as having fetuses with significant structural abnormalities, other than NTDs (<jats:italic>n<\/jats:italic> = 207) or AWDs (<jats:italic>n<\/jats:italic> = 254). In addition to the structural abnormalities, 225 cases of fetal demise, 4 molar pregnancies, 15 cases of twin\u2010to\u2010twin transfusion, and 92 cases with placental abnormalities were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While Prenatal Screening Programs do not explicitly screen for structural abnormalities other than NTDs and AWDs, clearly many other structural abnormalities may be associated with a screen\u2010positive status. Thus, the detection of these additional structural defects can be considered an ancillary program benefit. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2601","type":"journal-article","created":{"date-parts":[[2010,8,22]],"date-time":"2010-08-22T01:21:17Z","timestamp":1282440077000},"page":"981-987","source":"Crossref","is-referenced-by-count":6,"title":["Ancillary benefits of prenatal maternal serum screening achieved in the California program"],"prefix":"10.1002","volume":"30","author":[{"given":"N. Neely","family":"Kazerouni,","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Hodgkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Lorey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Roberson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/AOG.0b013e31819930b0","article-title":"ACOG Practice Bulletin No. 101: Ultrasonography in pregnancy","volume":"113","author":"ACOG Committee on Practice Bulletins","year":"2009","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_3_1","unstructured":"American College of Radiology.2007. 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