{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:02:45Z","timestamp":1790373765693,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12-13","license":[{"start":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T00:00:00Z","timestamp":1286496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated Septal Agenesis (SA) is a rare disease with clinical outcomes (especially neurological outcomes) that are unknown. The purpose of this study was to evaluate the clinical outcome of these children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicenter study of 17 children with an isolated SA or SA combined with a moderate ventricular dilatation (VD) that was diagnosed antenatally and confirmed by a magnetic resonance imaging (MRI) performed in the antenatal period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 17 children, 14 had normal neurological examinations, 2 had language development delay and visuo\u2010spatial dyspraxia, and 3 of the 17 children had behavioral problems. Eight children had neuropsychological evaluations, and the results were normal in six cases. There were 3 cases of septo\u2010optic dysplasia (SOD) diagnosed postnatally, which highlighted the difficulties in assessing the optic tract and hypothalamic\u2010pituitary region in antenatal imaging. Language delay and behavioral disorders were the main abnormalities at follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The discovery of an isolated SA reveals the difficulties of prenatal diagnosis to correlate the neurological and functional prognosis to morphological findings. The prognosis seemed to be good. It appears necessary to improve the diagnostic performance of fetal brain imaging and to follow\u2010up these children prospectively to assess their long\u2010term cognitive\u2010behavioral outcomes. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.2628","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T00:01:26Z","timestamp":1286496086000},"page":"1143-1150","source":"Crossref","is-referenced-by-count":41,"title":["Pediatric outcome of children with the prenatal diagnosis of isolated septal agenesis"],"prefix":"10.1002","volume":"30","author":[{"given":"L.","family":"Damaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bruneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010L.","family":"Moutard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Odent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Adamsbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tr\u00e9guier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1059664"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1997)10:4<245::AID-CA5>3.0.CO;2-R"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-999-0119-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19880501-11"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2928524"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.2.353"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1378-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.06.041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090010070029"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070130064032"},{"key":"e_1_2_7_12_1","first-page":"97","article-title":"Pituitary dysfunction, morbidity and mortality with congenital midline malformation of the cerebrum","volume":"158","author":"Cameron F","year":"1999","journal-title":"Endocrinology"},{"key":"e_1_2_7_13_1","first-page":"417","article-title":"Septo\u2010optic dysplasia: a literature review","volume":"74","author":"Campbell CL","year":"2003","journal-title":"Optometry"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.4.671"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053201"},{"key":"e_1_2_7_16_1","first-page":"267","article-title":"Studies on malformation of cranio\u2010encephalic sutures. 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