{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:15:07Z","timestamp":1792581307746,"version":"4.5.0"},"reference-count":110,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T00:00:00Z","timestamp":1294185600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective screening for major aneuploidies can be provided in the first trimester of pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum free\u2010\u03b2\u2010human chorionic gonadotrophin and pregnancy\u2010associated plasma protein\u2010A can identify about 90% of fetuses with trisomy 21 and other major aneuploidies for a false\u2010positive rate of 5%. Improvement in the performance of first\u2010trimester screening can be achieved by firstly, inclusion in the ultrasound examination assessment of the nasal bone and flow in the ductus venosus, hepatic artery and across the tricuspid valve, and secondly, carrying out the biochemical test at 9 to 10 weeks and the ultrasound scan at 12 weeks. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.2637","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T07:49:44Z","timestamp":1294213784000},"page":"7-15","source":"Crossref","is-referenced-by-count":526,"title":["Screening for fetal aneuploidies at 11 to 13 weeks"],"prefix":"10.1002","volume":"31","author":[{"given":"Kypros H.","family":"Nicolaides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341904"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70388-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.9.449"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1215"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7766"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00808.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.949"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb12973.x"},{"key":"e_1_2_9_10_1","first-page":"918","article-title":"Maternal serum pregnancy associated placental protein A and fetal nuchal translucency thickness for the prediction of fetal trisomies in early pregnancy","volume":"84","author":"Brizot ML","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_11_1","first-page":"1227","article-title":"Maternal serum hCG and fetal nuchal translucency thickness for the prediction of fetal trisomies in the first trimester of pregnancy","volume":"102","author":"Brizot ML","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.10.1087"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06601.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.336"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2405"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06709-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.12.057"},{"key":"e_1_2_9_18_1","volume-title":"Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment","author":"Cuckle H","year":"2009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2557"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<505::AID-PD572>3.0.CO;2-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2005.05.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1913"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2547"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1922"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2736"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150509"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140814"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.9.1071"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07040245.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07040239.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5332"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5331"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den224"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2149"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6412"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6318"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6264"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7663"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7646"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2057"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00881-4"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4029"},{"key":"e_1_2_9_44_1","first-page":"259","article-title":"Observations on an ethnic classification of idiots","volume":"3","author":"Langdon Down J","year":"1866","journal-title":"Lond Hosp Rep"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802430842"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00292.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2184"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90700-H"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6330"},{"key":"e_1_2_9_50_1","first-page":"2001","article-title":"First\u2010 and Second\u2010Trimester Evaluation of Risk (FASTER) Research Consortium. 2005. First\u2010trimester or second\u2010trimester screening, or both, for Down's syndrome","volume":"353","author":"Malone FD","journal-title":"N Engl J Med"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12060380.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1999"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90530-1"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7737"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199902)19:2<142::AID-PD486>3.0.CO;2-7"},{"key":"e_1_2_9_56_1","volume-title":"Ultrasound Markers for Fetal Chromosomal Defects.","author":"Nicolaides KH","year":"1996"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.128"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.090"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6831.867"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92240-G"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199805)18:5<519::AID-PD398>3.0.CO;2-U"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1860"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06060390.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1053"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb10902.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.8.565"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.010"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3907"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.12.029"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7549"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.288"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09550.x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09907.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10020086.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.9.2008"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07060421.x"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1044"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140706"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264259"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13030167.x"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11060391.x"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1775"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200008)20:8<683::AID-PD847>3.0.CO;2-M"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02222.x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13040231.x"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<411::AID-PD822>3.0.CO;2-2"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<390::AID-PD824>3.0.CO;2-B"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200006)20:6<495::AID-PD846>3.0.CO;2-U"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11619.x"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1258\/000456303321610501"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.186"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02246.x"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1923"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1035::AID-PD694>3.0.CO;2-2"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2185"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1897"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970121005"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90008-X"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00053-1"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410701"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta7110"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12680-3"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025273"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.974"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5299"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7755"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2643"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1382"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2664"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:52:19Z","timestamp":1694616739000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":110,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1002\/pd.2637"],"URL":"https:\/\/doi.org\/10.1002\/pd.2637","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}