{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:15:48Z","timestamp":1789078548808,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T00:00:00Z","timestamp":1297296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the ability of maternal serum\u2010free \u03b2\u2010human chorionic gonadotrophin (\u03b2\u2010hCG), pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A), and alpha fetoprotein (AFP) levels in the screening of fetuses with hemoglobin (Hb) Bart's disease among pregnancies at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the study. Maternal serum\u2010free \u03b2\u2010hCG, PAPP\u2010A, and AFP concentrations were measured before cordocentesis, and the final fetal diagnosis of Hb Bart disease was based on fetal Hb typing using high\u2010performance liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 57 recruited pregnancies, 11 had fetal Hb Bart's disease and 46 were unaffected. Maternal serum alpha\u2010fetoprotein (MSAFP) concentrations were significantly higher in women with fetal Hb Bart's disease than those with unaffected fetuses (median 99.53 vs 50.83, <jats:italic>P<\/jats:italic> &lt; 0.001), whereas the concentrations of free \u03b2\u2010hCG and PAPP\u2010A were not significantly different between the two groups (<jats:italic>P<\/jats:italic> = 0.543 and 0.777, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Second\u2010trimester MSAFP may be clinically a useful screening test for fetal Hb Bart's disease among pregnancies at risk. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2705","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T16:11:52Z","timestamp":1297872712000},"page":"430-433","source":"Crossref","is-referenced-by-count":9,"title":["Maternal serum hCG, PAPP\u2010A and AFP as predictors of hemoglobin Bart disease at mid\u2010pregnancy"],"prefix":"10.1002","volume":"31","author":[{"given":"Fuanglada","family":"Tongprasert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanane","family":"Wanapirak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theera","family":"Tongsong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"689","article-title":"Relationship between alpha\u2010fetoprotein and fetal erythropoiesis","volume":"44","author":"Bartha JL","year":"1999","journal-title":"J Reprod Med"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.728"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1351"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.4.262.265"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199711)17:11<1039::AID-PD191>3.0.CO;2-U"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050220"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/clinchem\/36.5.822","article-title":"Concentrations of alpha\u2010fetoprotein increased in maternal serum but normal in amniotic fluid in a pregnancy involving hemoglobin Bart's disease","volume":"36","author":"Manoukian AA","year":"1990","journal-title":"Clin Chem"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000228507.24471.1f"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199605)16:5<431::AID-PD877>3.0.CO;2-V"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)80031-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200006)20:6<495::AID-PD846>3.0.CO;2-U"},{"key":"e_1_2_5_13_1","article-title":"Reference range of fetal splenic circumference from 14 to 40 weeks of gestation","author":"Srisupundit K","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1027::AID-PD691>3.0.CO;2-C"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.12.807"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02390937"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.407"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2705","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.2705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.2705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:10:28Z","timestamp":1696677028000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.2705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,10]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/pd.2705"],"URL":"https:\/\/doi.org\/10.1002\/pd.2705","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,10]]}}}