{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:09:17Z","timestamp":1791864557852,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the usefulness of fetal echocardiography in the mid\u2010second trimester in predicting postnatal outcome of tetralogy of Fallot (ToF), focusing on the need for early intervention (EI) and surgery type: pulmonary valve\u2010sparing surgery (PVSS) versus placement of transannular patch (TAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Assessment of cardiac morphological and functional parameters in 23 live\u2010born fetuses with isolated ToF was performed at 19 to 22 and 34 to 38\u2009weeks. Comparisons were made between outcome groups (EI vs non\u2010EI and PVSS vs TAP). EI was considered as requirement either of palliative procedure or corrective surgery before three months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival was 96%. EI was required in 32% of cases and TAP in 50%. At 19 to 22\u2009weeks, a pulmonary valve peak systolic velocity (PVPSV) \u226587.5\u2009cm\/s predicted EI with 100% sensitivity and 93.3% specificity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). At 34 to 38\u2009weeks, the size of the pulmonary valve, pulmonary valve\/aortic valve and main pulmonary artery\/ascending aorta were significantly different, but the PVPSV again yielded the best performance: all cases undergoing EI and\/or TAP were selected using cut\u2010off of \u2265144.5\u2009cm\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The postnatal outcome of fetuses with ToF may be established using PVPSV from the mid\u2010second trimester. This may be useful in providing the most appropriate perinatal management and accurate parental counselling. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2844","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T10:06:37Z","timestamp":1315303597000},"page":"1126-1133","source":"Crossref","is-referenced-by-count":32,"title":["Tetralogy of Fallot: prediction of outcome in the mid\u2010second trimester of pregnancy"],"prefix":"10.1002","volume":"31","author":[{"given":"D.","family":"Escribano","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Hospital Universitario \u201812 de Octubre\u2019  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Herraiz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynaecology Hospital Universitario \u201812 de Octubre\u2019  Madrid 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