{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:29:16Z","timestamp":1761154156413},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,12]],"date-time":"2002-03-12T00:00:00Z","timestamp":1015891200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the outcome after fetal reduction or selective termination to singleton pregnancies for various indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal reduction or selective feticide to singleton pregnancies was performed in 80 multiple gestations (congenital malformations, 17 cases; high\u2010risk obstetric conditions, 25 cases; or social\/psychological indications, 38 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall pregnancy loss rate was 10%; however, pregnancy failure was significantly higher in selective reductions performed for preterm prelabor rupture of membranes (PPROM) (4\/8) compared with monochorionic twin and bad obstetric history. Fetal reduction to singletons for psychological reasons resulted in a pregnancy wastage of 5.3% (2\/38). Procedures performed at \u226414 weeks showed a significantly lower fetal loss rate (2\/61; 3.3%), a higher mean gestational age at delivery (38.3\u00b12.2 weeks), and a decreased prematurity rate (<jats:italic>p<\/jats:italic>\u22640.001). The number of reduced fetuses, prenatal diagnosis by chorionic villus sampling before the reduction and maternal age did not interfere with pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetal reduction to singleton pregnancies has a favorable outcome, especially when performed before 14 weeks of gestation. 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