{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:14:10Z","timestamp":1777695250820,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the outcome in a cohort of fetuses with isolated sacrococcygeal teratoma (SCT) in relation to the need for <jats:italic>in utero<\/jats:italic> intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed a cohort of fetuses prenatally diagnosed with SCT between September 2000 and December 2010. Postnatal outcomes were evaluated in relation to the need for intervention <jats:italic>in utero<\/jats:italic> by reviewing medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 35 fetuses diagnosed with SCT during the study period, ten were lost to follow up and three had been misdiagnosed as SCT. Among the remaining 22 cases, <jats:italic>in utero<\/jats:italic> interventions were performed in eight, including radiofrequency ablation (RFA) in four, shunt operations in two, RFA plus cyst aspiration in one, and RFA with subsequent shunt operation in one. Tumors of cases undergoing <jats:italic>in utero<\/jats:italic> intervention were larger with rapidly growing, more frequently vascular, and with associated polyhydramnios or cardiomegaly. The rate of preterm births was higher in the cases that underwent interventions compared with those that did not (7\/8 vs 2\/14). Only one tumor showed regression after RFA while the other seven increased in size. Median tumor size at birth was significantly larger in the intervention group than in the nonintervention group (136\u2009mm vs 80\u2009mm). The neonatal survival rate was 6\/8 for the prenatal intervention group and 14\/14 for the nonintervention group. Resection of SCT was required in all neonates. The most common complication after postnatal surgery was fecal incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetuses with SCT undergoing <jats:italic>in utero<\/jats:italic> intervention have worse prognostic features, yet their neonatal outcome is similar to those of fetuses not requiring intervention. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2865","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T11:17:18Z","timestamp":1319455038000},"page":"1217-1221","source":"Crossref","is-referenced-by-count":45,"title":["Perinatal outcome of sacrococcygeal teratoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Mi\u2010Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Ulsan College of Medicine Asan Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Kyung","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department 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