{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:32:31Z","timestamp":1791045151113,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) Assess sensitivity of the measurement of nuchal translucency (NT), for the prenatal screening of congenital heart defect (CHD) on population\u2010based data; (2) examine whether the sensitivity of NT varies for specific types of cardiac defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using population\u2010based data of the Paris Registry of Congenital Malformation for 935 fetuses with CHD and without chromosomal anomalies for the period 2001 to 2007, we calculated sensitivity of NT, its positive predictive value and likelihood ratio, for all CHD and for six types of CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensitivity of NT was 7.1 and 4.2% for the 2.5 and 3.5\u2009mm cut\u2010off values, respectively; when isolated ventricular septal defects were excluded, sensitivity increased to 9.9 and 6.3%. Positive predictive values were 1.1 and 3.2% for 2.5 and 3.5\u2009mm cut\u2010offs, respectively. Of the six defects examined, sensitivity of NT was highest for heterotaxy followed by hypoplastic left heart syndrome and coarctation of aorta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of CHD was about fourfold higher for fetuses with NT\u2009\u2265\u20093.5\u2009mm (3.2%) than in the general population. This higher risk is comparable to that of other risk factors commonly used for early referral to specialized echocardiography. Nevertheless, our results, suggest that NT is not a very effective or efficient tool for the prenatal screening of CHD. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.2883","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T10:23:44Z","timestamp":1319624624000},"page":"1264-1269","source":"Crossref","is-referenced-by-count":18,"title":["Measurement of nuchal translucency for prenatal screening of congenital heart defects: a population\u2010based evaluation"],"prefix":"10.1002","volume":"31","author":[{"given":"Jean\u2010Marie","family":"Jouannic","sequence":"first","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2010Obst\u00e9trique et Centre Pluridisciplinaire de Diagnostic Pr\u00e9natal de l'Est Parisien H\u00f4pital Armand Trousseau  APHP, Paris 6, 26 Avenue A. Netter 75012 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Claire","family":"Thieulin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM UMR S953, Recherches \u00e9pid\u00e9miologiques sur la sant\u00e9 p\u00e9rinatale et la sant\u00e9 des femmes et des enfants Universit\u00e9 Pierre et marie Curie  Paris 6, 82 Avenue Denfert Rochereau 75679 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Service de cardiop\u00e9diatrie H\u00f4pital Necker\u2010Enfants Malades  APHP, Paris 5, 149 rue de S\u00e8vres 75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Houyel","sequence":"additional","affiliation":[{"name":"Service de cardiop\u00e9diatrie Centre Chirurgical Marie Lannelongue  149 Avenue de la R\u00e9sistance 92350 Le Plessis Robinson 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